^(32)磷-玻璃微球区域给药治疗肝癌的实验研究和组织吸收剂量估算

An Experimental Study of Liver Cancer Through Local Administration of Phosphorus32 Glass Microspheres & Estimation of TissueAbsorbed Dose

目的：研究３２磷－玻璃微球（３２Ｐ－ＧＭＳ）区域给药的药代动力学特点，探讨靶组织内辐照量和吸收剂量的估算方法。方法：模拟人类对７只家猪经肝动脉灌注给药或间质注射，对２０只人肝癌移植瘤裸鼠瘤体内注射，动态观测３２Ｐ－ＧＭＳ的分布与放射性计数率的衰减。结果：３２Ｐ－ＧＭＳ通过肝动脉给药，可有效栓塞至肝窦前小动脉，通过瘤体内注射可滞留在靶组织内不被排泄，给药第１４天的衰减分数为０．４８，其有效半减期与３２Ｐ物理半衰期值接近。经计算，３２Ｐ－ＧＭＳ放射性活度为３７ＭＢｑ时，在１ｋｇ肝组织内完全衰变，组织所接受的宏观平均吸收剂量是７３２ｃＧｙ。结论：本研究为３２Ｐ－ＧＭＳ对肝癌治疗的实验研究和临床应用提供了科学的剂量学依据。３２Ｐ－ＧＭＳ区域给药的稳定性使它逐步成为一种安全有效的内放射治疗肝癌的重要手段。

bjective:To study the characteristics of pharmacokinetics of phosphorus32 glass microspheres(32PGMS) by local administration and probe into the evaluation method of irradiation and absorbed dose in target tissue.Method:32PGMS were given to 7 domestic pigs through hepatic arterial perfusion or interstitial injection by imitating human race and to 20 BALB/C bare mice with human liver cancer planted through intracancer injection.The distribution of 32PGMS and decay of radioactivity count rate were observed dynamically.Results:The small arteries before hepatic sinuses were blocked when 32PGMS were given through hepatic arterial perfusion.32PGMS were retained in target tissue without excretion through intracancer injection.Decay factor was 0.48 fourteen days after administration and the value of effective half life was close to that of physical half life of 32P.According to calculation,the average absorbed dose accepted by 1kg hepatic tissue is 732cGy after 32PGMS with radioactivity of 37MBq is totally decayed.Conclusions:This study provides a scientific dosiological basis for experimental and clinical application in treatment of liver cancer with 32PGMS.The local administration of 32PGMS will progressively become one of the most important,safe and effective means of internal radioactive therapy for hepatic cancer because of its stability.