血管内支架、冠状动脉支架及药物涂层支架

Endovascular stent, coronary stent and drug eluting stent

血管内支架的技术性能主要包括生物相容性、机械力学性能、抗腐蚀性和血液相容性。术后出现支架内再狭窄是血管内支架的主要并发症。冠状动脉血管内支架的设计分为传统设计方法和有限元分析方法,支架壁厚和金属表面积是支架设计的两个重要参数,其加工材料多为表面改性剂和可降解材料。药物涂层支架的涂层材料可分为无机涂层材料、高分子涂层材料和蛋白涂层材料,可以携带药物或者基因。通过有限元分析技术,可以了解支架的应力分布情况等信息,估计支架在血管内的疲劳寿命,减轻支架对血管壁的损害,优化支架结构设计,能够极大地促进心脑血管支架的研发进程。

The technical characteristics of endovascular stent include biocompatibility, mechanical mechanics property, corrosion proof and blood compatibility. Postoperational in-stent restenosis is the main complication of endovascular stent. Coronary stent can be designed using conventional method or finite element method. The design comprising two parameters are stent wall thickness and metal surface area. The manufacturing materials consist of Surface modifier and degradable materials. Drug during stent, which carries drugs or genes, are derived from inorganic materials, polymer materials or protein materials. By means of finite element technique, the stress distribution of the stent can be well investigated to estimate the fatigue longevity of the stent in vessels, relieve the damage of the stent to the vascular wall and optimize the structural design of the stent, which all contribute to promoting the development of cardiovascular stents.