摘要
应用国产旋转式伽玛刀，采用单焦点，高剂量，毁损犬脑右额叶，术后观察一般临床表现，ＭＲＩ及病理解剖变化，结果表明：犬脑经过１８０～２００Ｇｙ高剂量照射后，一般临床无明显异常改变。在６～８周内复查ＭＲＩ，在犬脑右额叶内可见一类圆形低信号区，边缘清晰，锐利。病理大体观，右额叶内可见一规整圆形毁损灶，中心呈凝固性坏死，坏死区与健康组织区的界限非常清楚，周围组织有轻度水肿。光镜下观察，毁损灶内细胞结构消失，周边水肿，有胶质细胞及毛细血管增生。
Purpose: Confirming the appling function of OUR-RGS and it's actual biological effectiveness by the experimental results of highdose group. Methods and materials: Random choosing 6 ordinary and healthy dogs from 1 to 1.5 years old and performing irradiation on the position of dog's right frontal portion as target which localizing and follow-up by the method of CT/MRI. Focal dose 180～200Gy and follow-up date about 40 days after irradiation. Using MRI to observe the changes of the target and then pathological examination. Results: No obvious abnormal symptoms of neurology and psychiatry. MRI showing almost rounded lowdense area with hyperdense zone boundary T1-weighted imaging in the coronal and transaxial plane. pathologyical exmination showing cheesy necrosis in the target and short edema, capillary proliferation and hemorrhage arounding it. Conclusion: OUR-RGS has predictional biological reactions of neurological tissue and is safe, reliable and available for clinical usage.
