高血压大鼠血浆神经肽Y含量的变化及培哚普利干预的研究

Plasma Neuropeptide Y in Spontaneously Hypertensive Rats and Perindopril Treatment

研究自发性高血压大鼠（ＳＨＲ）血浆神经肽Ｙ（ＮＰＹ）含量的变化及培哚普利对血浆ＮＰＹ含量影响。方法用放免分析法测定Ｗｉｓｔａｒ－Ｋｙｏｔｏ大鼠（ＷＫＹ）、ＳＨＲ及培哚普利干预后ＳＨＲ、ＷＫＹ血浆ＮＰＹ的含量。结果ＳＨＲ血浆ＮＰＹ含量明显高于ＷＫＹ，并且ＳＨＲ血压的高低程度与血浆ＮＰＹ的含量正相关；培哚普利在降血压的同时伴有血浆ＮＰＹ含量的降低，并且对ＷＫＹ血浆ＮＰＹ的含量影响更甚。结论ＮＰＹ可能在高血压的发生、发展中起到重要作用，在培哚普利降血压作用中可能有血浆ＮＰＹ含量下降这一因素参与。

Aim\ To investigate the plasma neuropeptide Y(NPY) and the effects of perindopril on NPY in spontaneously hypertensive rats(SHR) and WistarKyoto rats(WKY).\ Methods\ Radioimmunoassay was used to determined the plasma NPY levels.\ Results\ The NPY levels were higher in SHR than that in WKY, there was a close relationship between blood pressure in SHR and the plasma NPY levels.\ Peridopril could lower the plasma NPY levels in SHR and WKY, and the effect was greater in WKY than SHR. \ Conclusion\ NPY might be involved in the pathogenesis of hypertension, the decrease of NPY levels might be one of the antihypertensive mechanism of perindopril.