实验性高血压所致的脑卒中与静息心率的关系

Association Between Stroke Induced by Experimental Hypertension and Resting Heart Rate

为探讨高血压个体中脑卒中发生与静息心率的关系。方法将易卒中型肾血管性高血压大鼠（ＲＨＲＳＰ）中，已发生脑卒中者的卒中前静息心率与未卒中者同时期静息心率进行比较；并观察不同药物抗高血压治疗后，脑卒中发生与静息心率的关系。结果高血压对照组中，已卒中大鼠卒中前心率快于未卒中大鼠同时期心率；静息心率≥３３０ｍｉｎ－１者，自发脑卒中率高于静息心率＜３３０ｍｉｎ－１者。美托洛尔减慢静息心率，显著降低ＲＨＲＳＰ的自发脑卒中率。结论静息心率是ＲＨＲＳＰ自发脑卒中的一个危险因素，能适当减慢静息心率的抗高血压治疗，可能有利于预防脑卒中。

Aim\ To investigate the relationship between stroke onset and resting heart rate.\ Methods\ The resting heart rate(HR) in strokeprone renovascular hypertensive rate(RHRSP) with stroke was compared with that in SHRSP without stroke and after antihypertensive therapy the relationship between stroke onset and resting heart rate were also observed.\ Results\ Resting heart rate before stroke in the RHRSP with stroke was faster than that without stroke.\ The incidence of spontaneous stroke in the RHRSP with resting heart rate ≥330 min-1 was higher than that with resting heart rate <330 min-1.\ The incidence of stroke in metoprolol treated group was lowered.\ Conclusion\ The resting heart rate is one of the risk factors of stroke in RHRSP.\ Antihypertensive therapy that reduce resting heart rate might prevent the occurrence of stroke.