高血压患者血脂异常与红细胞胰岛素受体的关系

Relationship between Abnormality of Serum Lipids Levels and Erythrocyte lnsulin Receptor in Essential Hypertension

探讨血清脂质水平与胰岛素受体及胰岛素抵抗的关系。方法以１３例健康体检者为对照组，研究３７例原发性高血压患者红细胞胰岛素受体和血清脂质水平的变化。结果与对照组相比，原发性高血压患者红细胞胰岛素受体较少，血清总胆固醇（ＴＣ）、低密度脂蛋白胆固醇（ＬＤＬＣ）、低密度脂蛋白胆固醇／高密度脂蛋白胆固醇（ＬＤＬ／ＨＤＬ）均显著较高，载脂蛋白Ａ１（ＡｐｏＡ１）、ＡｐｏＡ／ＡｐｏＢ较低，高亲和力型红细胞胰岛素受体数目（Ｒ１）与ＴＣ、ＴＧ、ＬＤＬＣ呈显著负相关，与ＨＤＬＣ、ＡｐｏＡ１呈显著正相关。结论血脂导常可能与胰岛素受体减少有关。

Aim\ To investigate the relationship between levels of serum lipids and insulin receptors in essential hypertensive patients.\ Methods\ Erythrocyte insulin receptor(EIR) and serum lipids in 37 patients and 13 normal controls were examined.\ Results\ The numbers of EIR wre less in hypertension group than that in control group(P<001).\ TC,LDL C and the ratio of LDL/HDL was higher, but ApoA and the ratio of ApoA/AopB was lower in hypertensive subjects than that in controls.\ Negative linear correlations between EIR and serum lipid levels were shown in patients.\ Conclusion\ These findings indicate that insulin resistance may related to dyslipidemia.