冠脉通瘀汤对心肌缺血再灌注保护作用的研究

Protective Effects of Guanmaitongyu Decoction on Myocardial Ischemia reperfusion Injury in Rats

目的观察冠脉通瘀汤对大鼠心肌缺血再灌注的保护作用及对冠心病患者心电图的影响。方法(1)建立大鼠心肌缺血再灌注模型,给药后观察心肌组织血清指标,了解冠脉通瘀汤的心肌保护效果;(2)冠心病患者61例随机分为对照组30例与观察组31例,均予西医常规治疗,观察组加服冠脉通瘀汤。结果(1)冠脉通瘀汤能降低血清中肌酸磷酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)及丙二醛(MDA)的含量,并能提高心肌组织中超氧化物歧化酶(SOD)的水平;(2)冠脉通瘀汤可使患者心电图的缺血性改变改善更佳。结论冠脉通瘀汤对大鼠心肌缺血再灌注有治疗性和预防性保护作用,并能有效改善患者心肌缺血的心电图。

Objective： To investigate the protective effects of Guanmaitongyu Decoction（GMTYD） on myocardial ischemia reperfusion injury in rats as well as the electrocardiogram of the coronary heart disease patients. Methods： After making up the myocardial ischemia reperfusion injury model, the rats were given different dosages of drug. The protective effects of GMTYD on cardiac muscles were observed by detecting the index in blood serum. Besides, 61 cornary heart disease patients were divided into the control group with 30 patients and the treatment group with 31 patients randomly. The control group was given the original western medicine, while the treatment group was added GMTYD on the basis of western medicine. Compared with the electcardiograms before and after 3 months treatment. Results： The experiment indicated that GMTYD decreased MB isoenzyme of creatine kinase （CK - MB）, lactate dehydrogenase（LDH） and malondialdehyde（MDA） content in blood serum and also increased the content of superoxide dismutase（SOD） in cardiac musules. It improved the ischemia level on electcardiogram of patients. Conclusion： GMTYD has the therapeutic and preventive effect on myocaridal ischemia -reperfusion injury in rats and also availably improve the electcardiogram of the patients that suffer myocardial ischemia.