肺心病中医证型与炎症介质相关性探讨

The Correspondence Analysis of the Relationship between Syndrone Patterns of TCM and Inflammatory Mediators in Chronic Cor Pulmonale

目的探讨肺心病中医证型与炎症介质指标之间的关系。方法采用双抗体夹心ABC-ELISA法测定炎症介质TNF-α、IL-1β、IL-6、IL-8。结果痰热壅肺证TNF-α、IL-1β、IL-6为最高,与其它证型比较IL-6差异显著;阳虚水泛证IL-8最高,与痰浊蕴肺证及气阴两虚证比较差异显著。痰热壅肺证候积分与TNF-α、IL-8呈正相关,痰浊蕴肺证候积分与TNF-α呈正相关,阳虚水泛证候积分与TNF-α、IL-8均呈正相关。结论炎症介质指标在反映中医证候轻重上具有参考价值。

Objective： To investigate the relationship between syndrome patterns of TCM in Chronic Cor Pulmonale （CCP） and inflammatory mediators. Methods： The inflammatory mediators （TNF-α, IL- 113, IL -6, IL- 8） were tested by ABC -ELISA method. Results： The concentrations of plasma TNF-α, IL- 113, IL- 6 in Tanreyongfei group was highest among the four groups, and compared with the other groups, the value of IL - 6 increased sig- nificantly. The concentrations of plasma IL - 8 in Tanreyongl＇ei group was the highest, compared with the Tanreyongfei and Qiyinliangxu groups showed significant difference. In Tanreyongfei group and Yangxushuifan group, the syndrome points of TCM was obviously positive relation with the level of TNF -α and IL - 8. In Tanreyongfei group, it was obviously positive relation with the level of TNF -α. Conclusion： Inflammatory mediators has referenced worth for judging the illness degree of syndrome patterns of TCM in the CCP.