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单纯化疗与放化疗联合治疗局部晚期非小细胞肺癌临床分析 被引量:1

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摘要 目的:分析单纯化疗与放化疗联合治疗局部晚期非小细胞肺癌的疗效、毒性反应及对生存的影响。方法:回顾性分析2002年1月至2004年1月经病理学或细胞学确诊、随诊资料完整的初治及卡氏评分≥70的80例局部晚期非小细胞肺癌患者的临床资料,按治疗方法不同分为单纯化疗组45例和放化联合组35例,其中同期放化疗6例,夹心放化疗12例,序贯放化疗17例。放射治疗均采用三维适形放疗技术完成。结果:(1)单化疗和放化疗联合的近期疗效比较,差异无显著性(P>0.05);远期疗效比较,放化联合组的中位生存期,1、2、3年生存率两组间差异有显著性(P<0.05)。(2)两组患者主要毒副反应发生于消化道和造血系统,经检验无统计学差异(P>0.05)。结论:不能手术的局部晚期非小细胞肺癌采用放化疗联合治疗,可提高1、2、3年生存率,毒副反应可耐受。
出处 《实用医学杂志》 CAS 2008年第13期2255-2257,共3页 The Journal of Practical Medicine
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参考文献17

  • 1陈明,王卫华.局部晚期非小细胞肺癌放化综合治疗应用[J].肿瘤学杂志,2007,13(1):14-18. 被引量:3
  • 2韩宝惠.非小细胞肺癌治疗的循证医学新进展[J].上海医学,2005,28(6):451-455. 被引量:7
  • 3Furuse K, Fukuoka M, Kawahara M, et al. Phase Ⅲ study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vinblastine and cisplatine in unresectable stage Ⅲ non-small cell lung cancer [J]. J Clin Oncol, 2004, 17(2):2692 - 2699.
  • 4CurranW, Scott C, Langer C, et al. Phase Ⅲ comparison of sequential vs concurrent chemoradiation of pts with unresected stage Ⅲ non-small cell lung cancer ( NSCLC ) : initial report of Radiation Therapy Oncology Group (RTOG) 9410 [J]. Proc Am Soc Clin Oncol, 2004, 10(3) : 1891.
  • 5Albain K, Rusch V W, Crowley J J, et al. Concurrent cisplatin / etoposide plus chest radiotherapy followed by surgery for stage ⅢA (N2) and ⅢB non-small cell lung cancer: mature results of Southwest Oncology Group phase Ⅱ study 8805 [J]. J Clin Oncol, 2003,13(7) : 1880-1892.
  • 6Albain K S, Scott C B, Rusch V R, et al. Phase Ⅲ comparision of concurrent chemotherapy plus radiotherapy (CT/RT) and CT/ RT followed by surgical resection for stage Ⅲ A ( PN2 ) non-small cell lung cancer (NSCLC): initial results from intergroup trial 0139 (RTOC 93-09) [J]. Proc Am Soc Clin Oncol, 2004, 15 (6) : 2497.
  • 7徐嘉彰.肺癌综合治疗的部分进展探讨[J].临床肺科杂志,2006,11(3):281-281. 被引量:21
  • 8欧广飞,王绿化,张红星,陈东福,肖泽芬,冯勤付,周宗玫,吕纪马,梁军,汪楣,殷蔚伯.289例局部晚期非小细胞肺癌放疗和放化综合治疗结果[J].中华放射肿瘤学杂志,2007,16(2):86-90. 被引量:30
  • 9陈明.局部晚期非小细胞肺癌的放射加化疗综合治疗[J].中华放射肿瘤学杂志,2002,11(2):141-144. 被引量:36
  • 10Dillman R O, Hendon J, Seagren S L, et al. Improved survival in stage Ⅲ non-small-cell lung cancer: seven-year follow-up of cancer and leukemia group B (CALGB)8433 trial [J]. J Natl Cancer Inst, 1996, 88(3) : 1210-1215.

二级参考文献64

  • 1傅小龙,将国梁,王丽娟,钱浩,傅深,叶明,赵森.局部控制在非小细胞肺癌非手术治疗中意义的探讨[J].上海医学,1996,19(10):559-562. 被引量:20
  • 2王卫华,包勇,陈明,张力,李凯新,徐光川,邓小武,卢泰祥,崔念基.诱导化疗和紫杉醇每周同期化疗结合三维适形放射治疗不能手术的Ⅲ期非小细胞肺癌的初步结果[J].癌症,2006,25(10):1279-1283. 被引量:11
  • 3The International Adjuvant Lung Cancer Trial Collaborative Group. Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med, 2004, 350: 351-360.
  • 4Nakagawa M, Tanaka F, Tsubota N, et al. A randomized phase Ⅲ trial of adjuvant chemotherapy with UFT for completely resected pathological stage I non-small-cell lung cancer: the West Japan Study Group for Lung Cancer Surgery (WJSG)-the 4th study. Ann Oncol, 2005, 16: 75-80.
  • 5Hotta K, Matsuo K, Ueoka H, et al. Role of adjuvant chemotherapy in patients with resected non-small-cell lung cancer:reappraisal with a meta-analysis of randomized controlled trials. J Clin Oncol, 2004, 22: 3860-3867.
  • 6Alam N, Shepherd FA, Winton T, et al. Compliance with post-operative adjuvant chemotherapy in non-small cell lung cancer. An analysis of National Cancer Institute of Canada and intergroup trial JBR. 10 and a review of the literature. Lung Cancer, 2005, 47: 385-394.
  • 7Scagliotti GV, Novello S. Current development of adjuvant treatment of non-small-cell lung cancer. Clin Lung Cancer,2004, 6(suppl 2): S63-S70.
  • 8Belani CP. Adjuvant and neoadjuvant therapy in non-small cell lung cancer. Semin Oncol, 2005, 32(2 suppl 2): S9-S15.
  • 9Le Chevalier T, Lynch T. Adjuvant treatment of lung cancer:current status and potential applications of new regimens.Lung Cancer, 2004, 46(suppl 2): S33-S39.
  • 10Marino P, Preatoni A, Cantoni A. Randomized trials of radiotherapy alone versus combined chemotherapy and radiotherapy in stages Ⅲ a and Ⅲ b nonsmall cell lung cancer. A meta-analysis. Cancer, 1995, 76: 593-601.

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