局部振动对家兔血清单胺类神经递质的影响

Effects of Local Vibration on Serum Monoamine Neuro-transmitters of Rabbits

目的探讨振动对外周单胺类神经递质的影响,研究振动性神经损伤机制。方法将24只新西兰家兔随机分为低接振强度组[接振强度为ahw(4)3.03 m/s2]、中接振强度组[接振强度为ahw(4)6.13 m/s2]、高接振强度组[接振强度ahw(4)12.25 m/s2]和无接振对照组,用液相色谱-电化学检测法测定血清中单胺类神经递质:去甲肾上腺素(noradrenalin,NE)、5-羟色胺(5-serotonin,5-HT)和多巴胺(dopamine,DA)。结果振动中、高接振强度组血清中NE、5-HT和DA在接振不同时间,与相同时间段的对照组比较,均有明显升高(P<0.01),与同组接振前比较,也有明显升高(P<0.01)。总体上,随实验时间延长和接振强度增大,NE、5-HT和DA有升高趋势。结论振动可引起单胺类神经递质升高,可能参与振动性神经损伤机制。。

Objective To investigate the effects of local vibration on serum monoamine neuro-transmitters and the correlation with vibration-induced neural impairment. Methods Rabbits were divided into 4 groups at random. One was the control group and the other three groups EA group with the ahw （4） 3.03 m/s^2, B group with the ahw （4） 6.13 m/s^2 , C group with the ahw （4） 12.25 m/s^2] were tested at different levels of low, medium and high vibration power. Serum monoamine neuro-transmitters were measured in each group. Results With the increase of vibration power, the concentration of serum noradrenalin （NE）, 5- serotonin （5-HT） and dopamine （DA） had a tendency to significantly increase. Conclusions The local vibration may cause the changes of serum monoamine neuro-transmitters. The changes are related to vibration-induced neural impairment.