高压密封微波消解-ICP-AES法测定五种蒙药中无机元素

Determination of Inorganic Elements in Five Kinds of Mongolia Medicines by High Pressure Sealed Microwave Digestion-ICP-AES

采用HNO3-HClO4消解体系分别对额日敦-乌日勒、德都红花七味丸、通拉嘎-5、乌珠目-7、给旺-9等五种蒙药样品进行高压微波消解制样，利用电感耦合等离子体原子发射光谱法（ICP-AES）同时测定了镁、铝、钙、铬、锰、铁、钴、镍、铜、锌、砷、硒、锶、钼、银、镉和铅等17种无机元素的含量。通过添加标准回收实验，回收率均在97．25％～106．35％之间，验证了分析数据的可靠性。所有元素测定结果的相对标准偏差均小于3．3％，具有良好的准确度和精密度。实验结果表明，其中常量元素Ca，Mg和Fe，Mn，Zn，Cu的含量较高，测定结果可为开发研制蒙药新制剂、研制蒙药的质量控制标准和提高蒙药药效提供理论依据。

Five kinds of Mongolia medicines, Eridun-Urile, Deduhonghuaqiweiwan, Tonglage-5, Uzhumu-7 and Geiwang-9 are digested with HNO3-HClO4 system by high pressure system-sealed Microwave Digestion. The 17 inorganic elements content of magnesium, aluminum, calcium, chromium, manganese, ferrum, cobalt, nickel, copper, zincum, arsenic, selenium, strontium, molybdenum, silver, cadmium, plumbum in the solution are determined by ICP-AES. The results are proved to be reliable by adding standard recovery experiment. The recovery is 97. 48%-103.01% for Mg, 102.71%-105. 60%. for A1, 102. 00%- 105. 53% for Ca, 98. 78%-100. 34% for Cr, 101.93%-104. 65% for Mn, 100. 34%-104. 51% for Fe, 103.13%-105. 46% for Co, 100. 07%-103.22% for Ni, 97.25%-99.06% for Cu, 98. 57%-100. 10% for Zn, 102.35%-105. 37% for As, 100. 24%- 104.59% for Se, 99.19%-102.70% for Sr, 103. 35%-105.78% for Mo, 99.65%-101.32% for Ag, 102. 73%-105. 32% for Cd, and 104.76%-106.35% for Pb by this method. The relative standard deviation is less than 3. 3% for all the elements. And the method has high accuracy and good precision. The determination results indicate that the content of element in Five Kinds of Mongolia Medicines is 0-15 μg · g^-1 for Cd, Ag, As, Pb, Co, Ni, Cu; 15-100μg · g^-1 for Mo, Se, Zn, Cr; 100-3 000 μg· g^-1 for Mn, Sr, Fe, Mg, Al; 3 000-8 000 μg · g^-1 for Ca. Among of the five kinds of mongolia medicines, the content of elements has great differences. The order is Ca〉Mg〉Al〉Fe〉Mn〉Sr〉Se〉Zn〉Mo〉Cu〉Pb〉As〉Cr〉Ni〉Co〉Cd〉Ag for Eridun-Urile; Ca〉Al〉Fe〉Mg〉Mn〉Sr〉Se〉Mo〉Zn〉Ni〉Cr〉Cu〉Pb〉As〉Co〉Cd〉Ag for Deduhonghuaqiweiwan; Ca〉Fe〉Mg〉AI〉Mn〉Sr〉Se〉Zn〉Mo〉Cr〉Ni〉Cu〉Pb〉As〉Co〉Cd〉Ag for Tonglage-5, Ca〉Al〉Mg〉Fe〉 Sr〉Mn〉Se〉Zn〉Co〉Mo〉Cr〉Cu;〉Pb〉As〉Ag〉Ni〉Cd for Uzhumu-7 and Mg〉Ca〉AI〉Fe〉Se〉Mn〉Zn〉Sr〉Mo 〉Cu〉Cr〉Pb〉As〉Ag〉Co=Cd=Ni for Geiwang-9. The content of common elements Ca, Mg, Fe, Mn, Zn, Cu are higher. These results provide theoretical basis for developing quality control, improving the potency of Mongolia medicines and developing new Mongolia medicines.