精神分裂症患者血中SOD、GSH-PX、GSH及LPO的变化及临床意义的研究

Activity of plasma SOD,GSH PX and blood concentration of GSH,LPO in schizophrenics

应用超氧化物歧化酶超微量快速测定法、血中谷胱甘肽过氧化物酶活力测定法（ＤＴＮＢ）、二硫双硝基苯甲酸定量测定法和血清中丙二醛与硫代巴比土酸定量测定法（ＴＢＡ）测定４０例精神分裂症病人血中超氧化物岐化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）活力，还原型谷胱甘肽（ＧＳＨ）、脂质过氧化物（ＬＰＯ）含量，并与简明精神病量表（ＢＰＲＳ）总分、因子分、病人性别进行相关分析。结果表明：精神分裂症病人中血ＳＯＤ活力明显升高，与ＢＰＲＳ总分及五个因子分呈直线正相关，而ＧＳＨ－ＰＸ活力正常。ＧＳＨ含量明显下降，且与ＢＰＲＳ总分及因子３、４、５的分数呈直线负相关。血中ＬＰＯ含量正常。

The activity of plasma SOD.GSH PX and blood concentration of GSH,LPO were measured in 40 schizophrenics and in 40 normal controls.The results showed that the activity of SOD in patient group was higher significantly than that of normal controls.The activity of SOD was also positively correlated with scores of BPRS and its five factors in patient group.Blood concentration of GSH was lower significantly in patients group than in control groud,and it was negatively correlated with the score of BPRS and its third,forth and fifth factors.While the activity of GSH PX and blood concentration of LPO had no difference between patients and controls.These results suggest that free radical,lipid peroxidation are related to schizophrenia.As a biochemical basis for the pathophysiological mechanism of schizophrenia,it give us a clue to possible new treatment.