酒依赖高发家系成员听觉P3的对照研究

Controlled auditory P 300 study in densely alcoholism affected families

为了验证事件相关电位Ｐ３波幅降低是酒依赖的遗传标志的假说，作者在５个酒依赖高发家系３２名１８周岁以上成员（其中有１４名酒依赖者）和８个无酒依赖的对照家系４５名１８周岁以上成员中采用Ｏｄｄｂａｌ方法测查了听觉Ｐ３，结果发现，高发家系中的酒依赖者、非酒依赖者与对照家系成员之间的Ｐ３波幅和潜伏期差异均无统计学显著性。作者探讨了假说未得到验证的原因。

The purpose of this study was to validate whether decreased P 300 amplitude is a electrophysiological trait marker of alcoholism.Five densely affected families each with 2 or more alcoholics and 8 control families without alcoholics were identified according to DSM Ⅲ R and ICD 10 criteria of alcohol dependence.All members aging 18 or older in both family groups were examined with auditory P 300 using Oddball method.The results showed that there was no difference of statistical significance between alcoholics and non-alcoholic of both family groups.It was concluded that the data of this study failed to support the hypothesis that decreased P 300 amplitude is a trait marker of alcoholism, and the probable reasons were discussed.