3种广枣提取物对哇巴因诱发豚鼠心律失常作用的比较

Comparing the action of the three extracts in Choerospondias Axillaries (Roxb.)Burtt et Hill on arrhythmias induced by ouabain

目的:观察广枣中3种提取物对哇巴因所致心律失常的影响,为找到一种抗心律失常作用较强的主要化学单体或简单复合物打下基础。方法:采用Langendorg灌流法,观察药物对哇巴因所致离体豚鼠心脏心律失常的影响;给豚鼠恒速iv哇巴因致心律失常,观察药物的抗心律失常作用。结果:与空白对照组比,样品1、样品2使豚鼠离体心脏出现室颤时所需哇巴因的量增加,并呈明显的剂量依赖性;样品3使豚鼠离体心脏出现室颤所需哇巴因的量变化不大。样品1、样品2使哇巴因引起豚鼠早搏、室颤、室额、心脏停搏时的剂量明显增加,并呈明显的剂量依赖性:样品3使早搏、室速、心脏停搏时的剂量变化不明显,但可使室颤出现时的剂量明显降低。结论:样品1、样品2能对抗哇巴因所导致的心律失常的发生:而样品3不仅没有对抗作用,还有可能促进心律失常的发生。

Objective：To compare the actions of the three extracts in Choerospondias Axillaries （Roxb.）Burtt et Hill on arrhythmias induced by ouabain. Method：Langendorff perfuse was applied in the experiment, the antiarrhythmic action was to study by using ouabain on the guinea pig isolated heart;The antiarrhythmic action of the three extracts in Choerospondias Axillaries （Roxb.） Burtt et Hill was to study by using iv ouabain in guinea pig to induce arrhythmias. Result：compared with the NS group,Sample 1 and sample 2 both significantly prolonged the beginning time of VF ot isolated heart and increased the dosage of ouabain, Sample 3 didn＇ t change on the beginning time of VF of isolated heart;Sample 1 and sample 2 both greatly prolonged the beginning time of VE,VT, VF, HA;Sample 3 reduced the beginning time of VF. The actions of the three samples were in a concentration- dependent way. Conclusion： Sample 1 and Sample 2 both resisted the occurrence of arrhythmias induced by ouabain, Sample 3 and Sample 2 both resisted the occurrence of arrhythmias induced by ouabain, Sample 3 markedly promoted the occurrence of arrhythmias induced by ouabain.