乳腺癌患者血浆uPA、uPAR检测的临床意义

The clinical significance of the measuring the plasma level of uPA、uPAR for the patiants of breast carcinoma

目的探讨血浆uPA、uPAR水平在乳腺癌侵袭和转移评定的临床意义。方法采用ELISA方法,测定经组织病理学确诊的女性乳腺癌初治患者50例和健康女性体检者20例的血浆uPA、uPAR水平。结果乳腺癌患者血浆uPA、uPAR水平明显升高,与对照组比较差异有统计学意义(P<0.001);血浆uPA、uPAR水平随原发肿瘤的增大、腋淋巴结的转移以及分期而增高(P<0.05)。结论乳腺癌患者血浆uPA和uPAR的水平增高,与分期、腋淋巴结转移及原发肿瘤的大小密切相关,是乳腺癌侵袭和转移判定的有意义的指标。

Objective To study the clinical significance of the plasma levels of uPA,uPAR for the invasion and metastasis of the breast carcinoma. Methods Using ELISA method, measuring the plasma levels of uPA, uPAR of 50 female inpatients with breast carcinoma and 20 heathy cases, All patients visited a doctor for the first time. Results The plasma levels of uPA, uPAR in the patients with breast carcinoma were significantly higher than the ones in the healthy（P 〈0. 001 ） ;the increased plasma levels of uPA,uPAR were correlated with the pathology stage, axillary lymph node metastases and primary tumor size. Conclusion The plasma levels of uPA, uPAR in the patients with breast carcinoma were significantly high, and the increased plasma levels of uPA, uPAR were correlated with the pathological stage, axillary lymph node metastases and primary tumor size ;that were the significance indexs for predicting the invasion and metastasis of the breast carcinoma.