亚甲基四氢叶酸还原酶(MTHFR)基因多态性与胃癌易感性的Meta分析

META-ANALYSIS ON METHYLENE TETRAHYDROFOLATE REDUCTASE POLYMORPHISMS AND SUSCEPTIBILITY TO GASTRIC CANCER

[目的]运用Meta分析的方法综合评价MTHFR基因多态性与胃癌发病的关系。[方法]通过计算机检索中国生物医学文献数据库(CBM)和PubMed数据库,并结合文献追溯、网上查询(www.baidu.com;www.google.com)的方法,收集所有关于MTHFR基因多态性与胃癌易感关系的病例对照研究或队列研究报告。以胃癌组与对照组人群基因型分布的OR值为效应指标,各资料间进行一致性检验,以确定采用固定或随机效应模型进行合并分析。发表偏倚用漏斗图和失安全系数进行评估。所有统计分析应用RevMan4.2软件和SPSS13.0进行。[结果]共入选国内外相关文献19篇,累计病例3664例,对照5316例。MTHFRC677T基因多态和MTHFRA1298C基因多态合并OR值及其95%CI分别为1.28(1.13～1.46)和0.98(0.86～1.12)。按研究人群进行分层,东方人群MTHFRC677T基因多态合并OR值为1.35(1.20～1.52),西方人群MTHFRC677T基因多态合并OR值为1.19(0.83～1.72)。[结论]东方人群MTHFRC677T基因多态性与胃癌易感性有关,西方人群有待进一步研究;MTHFRA1298C基因多态性与胃癌易感性无统计学关联。

[Objective] To investigate the association between MTHFR polymorphism and susceptibility to gastric cancer by the method of recta-analysis. [Methods] Electronic search strategy was tanled out in CBM and PubMed database to collect case-control studies or cohort studies on association between MTHFR polymorphism and susceptibility to gastric cancer, also searched related literatures on the internet （www.baidu.com and www.google.com） as well as searched by tracing back literatures. Odds ratio was conducted to evaluate the genetypes of people in gastric cancer group and control group. Fixed or random effect models selected to analyze the data according to the heterogeneity which tested by chi-square test. Publication bias was assessed by using a funnel plot and fail-safe number. All statistical analysis was conducted with Review Manager 4. 2 and SPSS 13.0. [Results] A total of 3664 cases and 5316 controls were collected from 19 studies irrespective of the country. The pooled ORs （95%CI） for studies with polymorphisms of MTHFRC677T and MTHFRA1298C were 1.28 （1.13-1.46） and 0.98 （0.86- 1.12） respectively. Polymorphisms of MTHFRC677T were stratified by race, and the ORs for polymorphisms of MTHFRC677T among oriental and westerner were 1.35 （1.20-1.52） and 1.19 （0.83-1.72）, respectively. [Conclusion] Polymorphisms of MTHFRC677T among oriental have significantly significant association with gastric cancer, while not enough evidence can demonstrate that significantly association among westerner; Polymorphisms of MTHFRA1298C do not show significantly demonstrate with the susceptibility to castric cancer.