代谢综合征研究进展

Progress in study of metabolic syndrome

目的分析代谢综合征研究进展。方法现对代谢综合征的发病机理及防治作一综述。结果代谢综合征是以中心性肥胖、胰岛素抵抗、高血压、高三酰甘油血症、低高密度脂蛋白胆固醇、糖耐量下降或Ⅱ型糖尿病为主要特征的症候群,其病因学以肥胖为核心,同时遗传和环境因素、精神因素也是很重要的原因。发病机理主要以胰岛素抵抗为核心。美国国家胆固醇教育计划(NCEP)Ⅲ明确了代谢综合征的诊断标准及基本治疗原则,其中包括了通过改变生活方式改善胰岛素抵抗及相应的药物治疗。结论近年来,代谢综合征的发病原因及机制研究取得了很大的进展,但还需要人们在预防、治疗方面做更深入的研究,并广泛开展健康教育活动,积极预防。

Objective To analyze the advance of research on the metabolic syndrome. Methods The pathogenesis and the prevention and the treatment of the metabolism syndrome were reviewed. Results The metabolic syndrome is a group of symptoms characterized by the central obesity, insulin resistance, hypertriglyceridemia, high density lipoprotein-cholesterol, the decrease of glucose tolerance or diabetes mellitus Type Ⅱ. Its etiology centers on the obesity and also includes the heredity and environmental factors as well as the important psychological factors. The pathogenesis is mainly due to the insulin resistance. The U.S. National Cholesterol Education ProgramⅢ makes the diagnosis criteria for the metabolic syndrome and the fundamental treatment principles comprising the change of the mode of life, the improvement of the insulin resistance and corresponding medication. Gonciusion The greater advance of the research on the pathogenesis, etiology and mechanism for the metabolic syndrome has been achieved. However, further study on the prevention and treatment should be performed and the health education should be widely promoted.