冠状动脉病变与2型糖尿病及髓过氧化物酶关系的探讨

MYELOPEROXIDASE LEVEL IN PATIENTS WITH CORONARY HEART DIEASE COMPLICATING WITH OR WITHOUT DIABETES MELLITUS

目的:探讨冠状动脉病变与2型糖尿病和髓过氧化酶的关系。方法:对2006年9月至2007年9月在我院就诊的210例胸痛临床怀疑患冠心病的患者进行冠状动脉造影,将其中冠状动脉狭窄大于50%的160例患者按照2003中国糖尿病指南的标准分为糖尿病组和非糖尿病组。对两组同时进行髓过氧化物酶水平的测定。结果:不同髓过氧化物酶水平下冠状动脉病变类型的比较说明,随着髓过氧化物酶水平的升高,糖尿病组的冠状动脉病变严重程度增加,差异有统计学意义,特别是在髓过氧化物酶大于65.2Auu/L,这种差异更为明显。结论:髓过氧化物酶可以作为预测糖尿病合并冠状动脉粥样硬化性心脏病患者冠状动脉病变严重程度的预测指标。

Objective ：To observe the relationship between myeloperoxidase （MPO） level and coronary artery lesion in patients with coronary heart disease （CHD） complicating with or without diabetes mellitus（T2DM）. Methods：Out of 210 patients who were admitted in Neijiang first people＇s hospital because of chest pain,was diagnosed by coronary artery ang iography （CAG）.T2DM was diagnosed in 70 out of 160 CHD patients （DM group） ,and the relationship between MPO level and coronary artery lesion was compared between DM group and CHD patient without diabetes mellitus （non-DM group） . Results ：The number of CHD patients with type B and C coronary was more stenosis,and the MPO level was significantly higher in DM group than in non-DM group. Especially in patients with the MPO level 〉 65.2Auu/l.Conclusion：For CHD patients complicating with T2DM, MPO is a reliable marker to predict the severity of coronary artery lesion.