摘要
肝脏是脂类代谢的中心,肝细胞通过其细胞膜的毛细胆管面,每天分泌约1g胆固醇和4g卵磷脂(磷脂酰胆碱phosphaddyl—choline,PC)进入胆汁。胆汁中的卵磷脂有助于胆固醇的溶解,防止疏水的胆固醇分子在胆道内形成胆固醇性结石。胆盐是一种天然的离子型去垢剂,卵磷脂可灭活其去垢活性,防止对肝脏和胆道上皮细胞的损伤。
出处
《泸州医学院学报》
2008年第4期470-472,共3页
Journal of Luzhou Medical College
参考文献20
-
1Ronald PJ ,Oude E ,Guido NJ , et al. The role of mdr2 Pglycoprotein in hepatobiliary lipid transport[J].FASEB,1997; 11:19.
-
2Oude Elferink R. P, Paulusma C C.Funcfion and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein) [J].Pflugers Arch, 2007;453 (5) : 601.
-
3Gendrot C, Bacq Y, Brechot MC, et al.A second heterozygous MDP.3 nonsensemutation associated with intrahepatic cholestasis of pregnancy[J].Med Genet, 2003;3:32.
-
4Lincke CR, Smit .JJM, Van Der Velde Koerts T, et al. Structure of the human MDR3 gene and physical mapping of the human MDR locus[J]. Bio Chem, 1991;266:5303.
-
5Gros P, Raymond MJ . Cloning and characterization of a second member of the mouse mdr gene familiy[J]. Mol Cell Bio,1988;8:2770.
-
6Dixon PH, Weerasekera N,Linton KJ, et al.Heterozygous MDR3 missense mutation associated with intrahepafic ch- olestasis of pregnancy:evidence for a defect in protein trafficking[J].Hum Mol Genet, 2000;8:1209.
-
7Rosenberg MF, Velarde GF, Robert CM, et al.Reracking of transmembrane domains of P-glycoprotein during the transport ATPase cycle[J].EMBO, 2001;20 : 5615.
-
8黄建容,刘建.胆酸代谢与妊娠期肝内胆汁淤积症研究进展[J].重庆医学,2004,33(7):1113-1115. 被引量:6
-
9Smit JJ, Schinkel AH, Oude Elferink RPJ, et al. Homozygous- disrupton of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease[J]. Cell ,1993;75:451.
-
10Aleta RC, Alexander JS, Victoria CH, et al.Hepatic secretion of phospholidip vesicles in the mouse critically dependson MDR2 or MDR3 P-glycoprotein expression[J]. Clin Invest. 1997;10: 2562.
二级参考文献32
-
1Grober J.Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene.Involvement of the farnesoid Xreceptor/0-cis-retinoic axid receproe heterodimer[J].J Biol Chem,1999,274(42):29748
-
2Thompson R,Steautnieks S.BSEP:function and role in progressive familial intrahepatic cholestasis[J].Semin Liver Dis,2001,21(4):545
-
3Parks DJ.Bile acids:natural lignds for an orphan nuclear receptor[J].Science,1999,284(5418):1365
-
4Trauaer M,Boyer JL.Bile salt transports:molecular characterization function and regulation[J].Physiol Rev,2003,83(2):633
-
5Geier A,Dietrich CG.Regulation of basolateral organic anion transporters in ethinylesthadiol-induced cholestasis in the rat[J].Biochim Biophys Acta,2003,1609(1):87
-
6Traumer M,Arrese M.The rat canalicular conjugate export pump(Mrp2) is down-regulated in intrahepatic and obstructive cholestasis[J].Gastroenterology,1997,113(1):255
-
7Ortiz DF.MRP3,a new ATP-binding casstte protein localized to the canalicular domain of the hepatocyte[J].Am J Physiol,1999,276(6pt1):G1493
-
8Donner MG,Keppler D.Up-regulation of basolateral multidrug resistnce protein3(Mrp3) in cholestatic rat liver[J].Hepatology,2002,34(4pt1):768
-
9Yu J,Lo JL.Lithocholic and decreases expression of bile salt export pump through farnesoid X reepter antagonist activity[J].J Biol Chem,2002,277(35):31441
-
10Lee JM.Expression of the bile salt export pump is maintained after chronic xholestasis in the rat[J].Gastroenterology,2000,118(1):163
共引文献5
-
1李金艳,刘建.MDR3在妊娠期肝内胆汁淤积症发病机制中的作用[J].重庆医学,2005,34(4):611-613. 被引量:1
-
2王秦川,李金艳.FXR及其作用的靶基因[J].重庆医学,2006,35(12):1126-1128. 被引量:2
-
3陶林,段东,朱玉泉.血清CG测定在妊娠肝内胆汁淤积症中的临床意义[J].重庆医学,2007,36(7):636-637. 被引量:3
-
4李俊男,常青,史常旭,梁志清,江露.脐静脉内皮细胞在妊娠期肝内胆汁淤积症胎儿缺氧中的作用[J].重庆医学,2007,36(16):1623-1625. 被引量:2
-
5姚文丽,杜鹏,刘学,李莉,许乾丽,周威,吴林菁,贺智勇,沈祥春,陶玲,茅向军.急性肝损伤对注射用清开灵(冻干)体内药动学影响的研究[J].时珍国医国药,2019,30(1):65-69. 被引量:2
同被引文献5
-
1黄胜,胡元达,王若腾,左伟.肝内胆管结石术后复发40例临床分析[J].中国乡村医药,2007,14(10):23-25. 被引量:2
-
2Costamagna G, Tringali A, Shah SK, et al. Long - term follow - up of patients after endoscopic sphincterotomy for choledocholithia- sis, and risk factors for recurrence. Endoscopy,2002 ,34(4) :273- 279.
-
3孙燕兵,马一瀛,李靖,杨征宇.内镜时代的胆石症治疗[J].国际外科学杂志,2009,36(7):495-498. 被引量:5
-
4章一凡.排石汤加熊去氧胆酸治疗肝内胆管结石27例[J].湖南中医杂志,2009,25(6):58-58. 被引量:3
-
5王艳芬,张昕昕.优思弗对预防保胆取石术后结石复发的临床研究[J].肝胆外科杂志,2011,19(3):210-212. 被引量:25
二级引证文献6
-
1许红,黄启凌.熊去氧胆酸治疗早产儿胃肠外营养相关性胆汁淤积症[J].实用药物与临床,2012,15(12):820-821. 被引量:13
-
2顾生旺,蒋兆荣,刘欢,常成.国产熊去氧胆酸胶囊致严重过敏性荨麻疹1例[J].肝脏,2013,18(10):723-723. 被引量:3
-
3黄咏妍.针对性饮食宣教对泌尿系结石患者饮食依从性与结石复发率的影响[J].齐鲁护理杂志,2016,22(2):118-120. 被引量:3
-
4钟琼.熊去氧胆酸治疗婴儿胆汁淤积症疗效观察[J].国际医药卫生导报,2017,23(15):2435-2436. 被引量:1
-
5全红梅,林青龙,张春子.熊去氧胆酸胶囊治疗胆囊结石的临床研究[J].中国处方药,2018,16(2):88-89. 被引量:2
-
6刘晶,段炜,张进生,杨海宁,孙鹃,闫鲲,惠增骞.消石利胆胶囊与熊去氧胆酸胶囊治疗慢性胆固醇性结石性胆囊炎效果对比[J].武警后勤学院学报(医学版),2018,27(4):334-336. 被引量:7
-
1花荣,曹晖,吴志勇.MDR3型P-糖蛋白在胆汁脂类转运中的作用[J].中国临床医学,2003,10(5):777-779. 被引量:1
-
2宋盛春.皮肤不老的传说[J].现代健康人,2004,7(12):52-52.
-
3别平,范毓东.胆囊结石发病机理的研究进展[J].中国普外基础与临床杂志,2003,10(5):439-441. 被引量:9
-
4梅林,李学军.化学修饰的siRNA首次成功用于降低动物总胆固醇[J].生理科学进展,2005,36(3):229-229.
-
5张新洽,欧阳斌,华沪玮,曾可伟.乙型肝炎病毒感染与ABCB4基因及胆囊胆固醇结石形成的关系[J].广东医学,2015,36(19):2979-2980. 被引量:2
-
6江山,廖小丽,徐向刚,肖瑾.胆固醇分子强电场效应的从头算理论研究[J].电子科技大学学报,2003,32(6):729-731.
-
7陆忠华.CD25/IL-2Ra——一种很好的肝毛细胆管标记物[J].国际免疫学杂志,2006,29(4).
-
8姚曙光,邱树敏,李一万,易图明.病理材料中的胆固醇结晶与胆固醇性浆膜炎[J].临床与实验病理学杂志,1994,10(1):68-69. 被引量:3
-
9宫磊,朱延玲,胡卫华,孔丽娜,李铁臣.妊娠期肝内胆汁淤积症中ABCB4基因外显子12突变的研究[J].中国优生与遗传杂志,2007,15(2):17-18. 被引量:1
-
10吴军,张燕燕.骨髓间充质干细胞生物学特性及临床应用进展[J].中国组织工程研究与临床康复,2007,11(50):10134-10137. 被引量:6