摘要
目的评估血管内皮抑素对lewis肺癌的抗肿瘤作用。方法将lewis肺癌细胞系和荷lewis肺癌细胞的C57鼠分别进行不同剂量血管内皮抑素的药敏试验。结果血管内皮抑素可以诱导细胞凋亡,凋亡程度与内皮抑素剂量呈正相关。内皮抑素对鼠lewis肺癌有明显的抑瘤作用和抗肿瘤肺转移作用,也明显抑制血管内皮生长因子(VEGF)和微血管密度(MVD)的表达,作用程度与内皮抑素剂量呈正相关。应用内皮抑素未观察到消化道反应等类似化疗的副作用,也未观察到其它严重不良反应。结论血管内皮抑素有抗肿瘤生长作用。
Objective To assess the effect of endostatin on Lewis pulmonary carcinoma. Methods The effect of endostatin with diferent doses on lewis lung cell and C57 mice transplanted lewis lung carcinoma model were experimentally observed for duration of 10 days. Results Eendostatin could induce cellular apoptosis and the extent of apoptosis was positively correlated with the dose of endostatin. Eendostatin could inhibit the proliferation and metastasis of carcinoma positively correlated with the dose used. Endostatin could also inhibit the expression of VEGF and MVD of lewis pulmonary carcinoma and the effect was also positivly correlated with the dose used. Conclusion Eendostatin is capable of inhibiting the growth of lewis pulmonary carcinoma.
出处
《中国热带医学》
CAS
2008年第8期1307-1309,1323,共4页
China Tropical Medicine
