川崎病患儿血降钙素原水平检测临床意义的研究

Detection and clinical significance of level of procalcitonin in chidlren with Kawasaki Disease

目的观察川崎病患儿血清降钙素原（PCT）水平变化，探讨其在川崎病中的临床意义。方法以2005年1月-2007年10月住院的88例川崎病患儿为研究对象，分为冠脉扩张组（32例）及无冠脉扩张组（56例），采用胶体金免疫结合法测定血清PET水平，并与对照组35例健康儿童比较。结果采用积分法发现川崎病患儿PET水平较对照组增高，其差异有统计学意义（t=11.08，P〈0.01），川崎病患儿PCT阳性率73.9％，对照组PCT阳性率14.2％，差异有显著性（x^2=36．25，P〈0．01）。采用积分法发现川崎病患儿有冠脉扩张组PCT水平与无冠脉扩张组无明显差异（t=0．31，P〉0．05），川崎病患儿有冠脉扩张组PCT阳性率68．7％，无冠脉扩张组PET阳性率76．7％，差异无统计学意义（X^2=0．68，P〉0．05）。结论川崎病患儿血PCT水平明显增高，有无冠状动脉扩张患儿血PET水平变化不大，提示PET在川崎病诊断中可作为一项重要的参考指标，但对于冠状动脉扩张预测尚有待于进一步研究。

Objective To study the changes of level of serum procalcitonin （PCT） in children with Kawasaki disease （KD） and explore the clinical significance of PCT. Methods From Jan 2005 to Feb 2008,88 children suffering from KD and thirty three healthy children were recruited in this study. ,which were devided into eoranary arery dilatation gropu consisted of 32 eases and without coronary artery dilatation group consisted of 56 eases. The concentration of serum PCT of KD patients were detected with gold immunobinding assay amd compared with health children. Results The Levels of PCT in KD group were significantly higher than those of health group （ P 〈 0.01 ）. The positive rate of levels of PCT in KD group and control group were 73.9% and 14.2% respectively （P 〈 0.01 ） without showing a statistical difference between the patients with coronary artery dilatation and the patients without coronary artery dilatation （P 〉 0.05 ）. Positive rate of levels of PCT were 68.7% in the KD group with coronary artery dilatation and 76.7% in the KD group without coronary artery dilatation （ P 〉 0.05）. Conclusion The levels of serum PCT are significantly elevated in patients with KD. There is no significant differenee from the patients with coronary artery dilatation and those without cardiac complications, suggesting that PCT is an important indicator in diagnosis of KD.