摘要
目的:评估布托啡诺鼻喷剂用于妇科腹腔镜术后镇痛的有效性及安全性。方法:将54例患者随机分为布托啡诺组和对照组,每组27例患者。布托啡诺组用2mg布托啡诺喷鼻;对照组用安慰剂喷鼻。结果:在给药后15、30、60、180min,布托啡诺组VAS评分明显低于对照组(P<0.05);布托啡诺组在术后使用哌替啶的例数(1/27)明显低于对照组(17/27),P<0.05。两组患者不良反应的发生率无明显差异(P>0.05)。结论:布托啡诺鼻喷剂用于妇科腹腔镜手术患者镇痛效果明显,不良反应较少。
Objective:To investigate the efficacy and safty of transnasal butorphanol for postoperative analgesia in adult female who suffered gynaecological laparoscopic surgery. Methods: 54 patients undergoing gynaecological laparoscopic surgery with general anesthesia were enlisted into the test, who were randomly divided into two groups(n= 27). Postoperatively,cases in butorphanol group received butorphanol 2mg transnasally, and cases control group received placebo. The visual analogue scores at 0,15,30,60,180,360min postoperation and consumption of pethidine were recorded. The changes of mean artery pressure,heart rate,Spo2 and respiratory frequency were collected. The incidence of side effects such as vomit, itch and somnolence was compared between two groups. Results;Transnasal butorphanol produced clear analgesic effect compared with placebo,indicating lower analogue scores at 30,60,180min and demanding less pethedine. All women possessed stable vital signs and side effects were not signifficantly different between two groups. ConclUsions: Transnasal butorphanol could effectively relieve postoperative pain in adult female patients who suffered gynaecological laparoscopic surgery. Its side effects were acceptable.
出处
《河北北方学院学报(医学版)》
2008年第4期20-22,共3页
Journal of Hebei North University:Medical Edition
关键词
妇科外科手术
腹腔镜检查
镇痛
布托啡诺
Gynecologic Surgical Procedures,Laparoscopy,Analgesia,Butorphanol