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脂蛋白相关磷脂酶A_2在动脉粥样硬化中的作用 被引量：2

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摘要 人血浆脂蛋白相关磷脂酶A2(Lp-PLA2)又称血小板活化因子乙酰水解酶(PAF-AH),主要由巨噬细胞合成和分泌。大部分Lp-PLA2与低密度脂蛋白结合,能水解灭活血小板活化因子,水解低密度脂蛋白上的氧化磷脂,生成溶血卵磷脂和氧化型游离脂肪酸,因此既有抗炎抗动脉粥样硬化,又有促炎促动脉粥样硬化的作用。近年来,越来越多的研究表明,Lp-PLA2具有促动脉粥样硬化作用,是心血管病的风险预测因子,可能成为心血管病新的治疗目标。
作者 李宁 顾水明 魏盟
机构地区 上海交通大学附属第六人民医院心内科 上海市徐汇区中心医院心内科
出处 《国际心血管病杂志》 2008年第4期212-215,共4页 International Journal of Cardiovascular Disease
关键词 脂蛋白相关磷脂酶A2 炎症 动脉粥样硬化
分类号 R543.5 [医药卫生—心血管疾病]
  • 相关文献

参考文献15

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共引文献30

同被引文献27

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国际心血管病杂志
2008年 第4期

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