子宫内膜癌患者血清CA125水平与预后关系的再评价

Re-evaluating the relationship of serum CA125 value and prognosis in endometrial cancer

目的探讨术前血清CA125水平指导子宫内膜癌治疗的价值。方法利用放射免疫法检测147例子宫内膜癌患者术前血清CA125水平。结果Ⅲ、Ⅳ期子宫内膜癌患者的CA125水平明显高于I、Ⅱ期（P〈0．01），CA125〉20kU／L诊断子宫内膜癌的敏感度和特异度分别为70．7％和98．0％。CA125〉35 kU/L诊断子宫内膜癌的敏感度和特异度分别为52．8％和100．0％。淋巴结转移阳性的患者血清CA125水平高于淋巴结转移阴性的患者。结论血清CA125值的检测对诊断子宫内膜癌及判断预后有一定的价值。

Objective To investigate the rule of various CA125 value in serum in instructing the treatment of endometrial cancer. Method The preoperative CA125 serum level of 147 cases of endometrial cancer was examined by radioimmunoassay. Results Among patients with endometrial cancer, the CA125 level was higher in stages Ⅲ and Ⅳ than that in stages Ⅰ and Ⅱ （P〈 0.01 ）. The sensitivity and specificity of CA125 〉 20 kU/L in diagnosis of the endometrial cancer were 70.7% and 98.0%, and CA125 〉 35 kU/L were 58.2% and 100.0%, respectively. The CA125 value of cases with cytological positive in abdomen was higher than that of cases with cytological negative. Conclusion The examination of CA125 serum levd is valuable in the judgement of operative stages and lymph node metastasis in endometrial cancer.