急性脑出血并发全身炎症反应综合征致多器官功能障碍综合征患者血清抗凝血酶及血浆肿瘤坏死因子-α的变化

Changes of antithrombin and tumor necrosis factor-α in plasma in acute cerebral hemorrhage with multiple organ dysfunction syndrome caused by systemic inflammatory response syndrome

目的探讨急性脑出血并发全身炎症反应综合征(SIRS)致多器官功能障碍综合征(MODS)患者血清抗凝血酶(AT)及血浆肿瘤坏死因子-α(TNF-α)含量的变化。方法用全自动免疫比浊定量分析法和酶联免疫吸附法(ELISA)对103例急性脑出血并发SIRS致多器官功能障碍综合征患者及30例健康体检者在人院后第一天的血清AT及血浆TNF-α含量进行测定。结果与正常对照组相比,急性脑出血并发全身炎症反应综合征致多器官功能障碍综合征患者血清AT水平明显下降,而血浆TNF-α含量显著升高,具有统计学差异(P<0.05)。结论急性脑出血并发全身炎症反应综合征致多器官功能障碍综合征患者血清AT含量下降,而血浆TNF-α含量升高,从而提示炎症细胞因子与凝血系统之间可能存在相互作用的关系,TNF—d、AT等细胞因子可作为预测MODS的早期指标。

Objective To investigate the clinical significance of changes in proinflammatory cytokines and coagulation system in the patients with acute cerebral hemorrhage with multiple organ dysfunction syndrome [MODS] caused by systemic inflammatory response syndrome [SIRS]. Methods Compared the data from 103 ease of patients with acute cerebral hemorrhage with MODS caused by SIRS with those from 30 healthy persons at the first day after admission. The level of antithrombin was measured by photometry immune-turbidimetric test with automated biochemical analysis. While the quantity of tumor necrosis factor-α was measured by enzyme linked immunosorbant assay. Results Antithrombin decreased but tumor necrosis factor-or markedly increased in acute cerebral hemorrhage with MODS caused by SIRS compared with those of healthy persens （P〈 0.05）. Conclusion Results suggested that proinflammatory cytokines might have some connection with the coagulation system. They can be regarded as laboratory index for judging the condition and prognosis in patients with cerohral hemorrhage.