摘要
目的设计并合成沙利度胺的衍生物。方法氨基酸苄酯氨解N-邻苯二甲酰基-L-谷氨酸酐,所得产物经氢化脱苄后再与氨气成铵盐即得1,3-二氢-1,3-二酮-2H-异吲哚衍生物。结果成功地合成了4个未见文献报道的沙利度胺衍生物。并进行了结构表征。结论利用本方法可以在温和的条件下获得较高产率的目标产物。
Objective To synthesize a series of derivatives of Thalidomide.Methods The N-Phthaloyl-L-glutamic anhydride was ammonolyzed with amino acid benzyl esters,followed by hydrogenization.The reaction between the hydogenized products and ammonia gas produced ammonium salt,1,3-dihydro-1,3-dioxo-2H-isoindole derivatives.Results Four new derivatives of Thalidomide were obtained and confirmed by spectral detection.Conclusion The derivatives of Thalidomide can be efficiently synthesized under mild conditions.
出处
《四川大学学报(医学版)》
CAS
CSCD
北大核心
2008年第4期645-647,共3页
Journal of Sichuan University(Medical Sciences)