影响胰岛移植治疗糖尿病远期效果的因素

Factors influence long-term effect of diabetes mellitus treated by islet transplantation

胰岛移植是治疗胰岛素依赖型糖尿病的一种有效方法,目前在国际上有取代胰腺移植的趋势。人的胰岛移植虽然已在临床成功地开展,但胰岛移植的长期疗效还不能令人满意。导致胰岛功能丧失的原因至今仍不完全清楚。因此,深入研究影响移植胰岛存活的因素,对于提高胰岛移植的长期疗效具有非常重要的意义。胰岛移植糖尿病患者的选择、组织配型,胰腺器官的采集、保存和运输,胰岛细胞的分离和纯化,胰岛移植的实施,胰岛移植期间患者的血糖控制和免疫抑制药的应用,胰岛移植后的功能评估等等,每个技术环节完成的质量,都是影响到胰岛移植的因素。

Islet transplantation is an effective method treating insulin-dependent diabetes mellitus, which is apt to supersede pancreas transplantation currently. Although human islet transplantation has already performed successfully, its long-term effect is still unsatisfying. Reasons causing loss of islet function is still not fully understood to date. Thus, deep research of factors influencing transplanted islet survival is of importance to improve long-term effect of islet transplantation. Patient selection and tissue matching, collection, preservation and transport of pancreatic organ, isolation and purification of islet cells, implement of islet transplantation, blood glucose control and immunosuppressive drug application during islet transplantation period, functional assessment after islet transplantation, etc. completion quality of each of these technical links is the factor influencing islet transplantation.