摘要
[目的]探讨以纤维蛋白复合脱蛋白松质骨作为骨形态发生蛋白(BMP)的载体修复兔节段性骨缺损。[方法]于36只青紫蓝兔两侧桡骨干处造成1.5 cm缺损,采用三种方法进行处理:A组,植入脱蛋白松质骨、纤维蛋白、BMP的复合物;B组,植入脱蛋白松质骨;C组,空白对照。术后2、4、8、12、16周进行放射学、组织学和电镜检查。[结果]A组骨缺损区在成骨活跃程度、骨再生量和再生髓腔结构等方面均显著优于B组,使骨缺损得到了较彻底的修复。B、C两组均不能产生骨性愈合。[结论]脱蛋白松质骨复合纤维蛋白是较理想的BMP载体材料,以三者的复合物修复骨缺损可达到满意效果。
[ Objective] To repair segmental bone defect with the composite of deproteinised cancellous bone, bone morphogenetic protein （BMP） and fibrin. [ Method] Bone defects were created in 36 New Zealand rabbits on the bilateral radii and treated with three kinds of implantations ： A, composite of deproteinised cancellous bone, BMP and fibrin; B, of deproteinised cancellous bone ; C, blank control. The defects were observed by entgenography, optical microscopy, and electron - microscopy at 2, 4, 8, 12, 16 weeks. [ Result] The defects treated with A implantation regenerated much more new bone and bridged earlier than the defects treated with B implantation and got completely repaired 16 weeks after operation. The defects with B and C implantation couldn＇t get osseous tissue healing. [ Conclusion] The composite of deproteinised cancellous bone, bone morphogenetic protein （BMP） and fibrin can be effectively used to repair segmental bone defect.
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2008年第13期1019-1022,共4页
Orthopedic Journal of China
关键词
脱蛋白松质骨
纤维蛋白
BMP
组织工程
骨缺损
修复
deproteinised cancellous bone
fibrin
bone morphogenetic protein （BMP）
tissue engineering
bone defect
repair
