恶性黑色素瘤选择性表达孕激素受体并与PCNA呈负相关性

Selective Expression of Progesterone Receptor in Malignant Melanoma Reversely Correlated with PCNA

目的探讨孕激素受体(PR)在恶性黑色素瘤(MM)中的表达情况及意义。方法以免疫组化法检测35例MM患者标本,8例痣细胞痣PR及增殖性细胞核抗原(PCNA)的表达,并结合临床及组织病理学资料进行分析。结果在MM中PR的阳性表达率为25.7%,在痣细胞痣中无表达。MM中PR表达与PCNA表达显著负相关。女性、年龄≤55岁、病程>1年、溃疡以及非肢端型组织亚型PR阳性比例增高,但均无统计学意义。结论PR在MM中选择性表达并可能具有抗增殖作用。

Objective To investigate the role of progesterone receptor （PR） expression in malignant melanoma （MM）. Methods PR and proliferative cell nuclear antigen（PCNA） expression in a series of 40 specimens from 35 patients with MM were evaluated by immunohistochemistry, and the correlation between the immunohistochemistry findings and clinicohistopathology date was also analyzed. Results PR expression was 25.7% （9/35）of MM. No PR expression was observed in nevi. PR expression was significantly inversely correlated with PCNA expression. There was a slight increasing of PR expression in female, aged less than 55 years, diagnosis delay longer than 1 year, ulceration and non-acral histopathology subtype, but not reaching statistic significance. Conclusion Selective expression of progesterone receptor in malignant melanoma correlated with tumor growth inhibition.