奥卡西平联合西比灵治疗晚发性难治性癫痫的临床研究

Treatment of late-onset refractory epilepsy by oxcarbazepine combined with sibelium

目的观察和评价奥卡西平联合西比灵治疗难治性癫痫的疗效。方法对30例晚发性难治性癫痫患者予奥卡西平联合西比灵治疗,以同期30例患者单用奥卡西平治疗作为对照,随访1年。结果验组总有效率56.7%,2例出现嗜睡、头晕、恶心、呕吐和疲劳等不良反应;对照组总有效率为46.7%,4例出现嗜睡、头晕、恶心、呕吐等不良反应。结论奥卡西平联合西比灵治疗晚发性难治性癫痫比单用奥卡西平治疗疗效较好,不良反应未见增加。

Objective To evaluate the clinical efficacy of oxearbazepine combined with sibelium on the patients with late-onset refractory epilepsy. Methods Thirty patients with late-onset refractory epilepsy received a combination treatment of oxcarbazepine and sibe- lium. The other 30 patients with late-onset refractory epilepsy treated by oxcarbazepine alone served as the control group. Results Seventeen patients （56.7%） in the combination treatment group were respond to the treatment, but 10 patients （46.7%） in the control group （P 〈 0.05）. Mild adverse reactions, such as drowsiness, dizziness, nausea and vomiting, occurred in 2 patients in the combination group, while 4 eases in the control group. Conclusions Treatment of oxcarbazepine combined with sibelium is more effective than oxcarbazepine use alone in patients with late-onset refractory epilepsy.