颅脑外伤后的靶向神经保护
摘要
颅脑外伤是当今威胁人类生命的主要疾患之一。在颅脑外伤后的神经保护方面,缺乏有效的药物治疗是目前一个备受关注的问题。近年来研究证实:AMPA受体拮抗剂、多种酶抑制剂、米诺环素和雌激素等具有神经保护作用。
出处
《国际神经病学神经外科学杂志》
2008年第3期221-224,共4页
Journal of International Neurology and Neurosurgery
基金
国家自然科学基金资助项目(30371454)
联合基金(GM)资助项目(30422201)
参考文献25
-
1Thurman DJ, Alverson C, Dunn KA, et al. Traumatic brain injury in the United States: A public health perspective. J Head Trauma Rehabil, 1999, 14 (6) : 602-615.
-
2Marklund N, Bakshi A, Castelbuono DJ, et al. Evaluation of pharmacological treatment strategies in traumatic brain injury. Curr Pharm Des, 2006, 12(13) :1645-1680.
-
3Matucz E, Moricz K, Giqhr G, et al. Reduction of cerebral infarct size by non-competitive AMPA antagonists in rats subjected to permanent and transient focal ischemia. Brain Res, 2004, 1019(1-2) :210-216.
-
4Belayer L, Alonso OF, Liu Y, et al. Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumarie brain injury in rats. J Neurotrauma, 2001, 18 (10).1031-1038.
-
5Furukawa T, Hoshino S, Kobayashi S, et al. The glutamate AMPA receptor antagonist, YM872, attenuates cortical tissue loss, regional cerebral edema, and neurological motor deficits after experimental brain injury in rats. J Neurotrauma, 2003, 20(3) :269-278.
-
6Weiser T. AMPA receptor antagonists with additional mechanisms of action: new opportunities for neuroproteetive drugs ? Curr Pharm Des, 2002, 8(10) :941-951.
-
7Wang KK. Calpain and easpase : can you tell the difference ? Trends Neurosci, 2000, 23 ( 1 ) : 20-26.
-
8Kupina NC, Nath R, Bemath EE, et al. The novel ealpain inhibitor SJA6017 improves functional recovery after delayed administration in a mouse model of diffuse head injury. J Neuotrauma, 2001, 18(11) :1229-1240.
-
9Shirasaki Y, Miyashita H, Yamaquchi M, et al. Exploration of orally available calpain inhibitors: peptidyl alpha-ketoamides containing an amphiphile at P3 site. Bioorg Med Chem, 2005, 13(14) :4473-4484.
-
10Han BH, Xu D, Choi J, et al. Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of call death after neonatal hypoxic-ischemic brain injury. J Biol Chem, 2002, 277(33) : 30128 -30136.
二级参考文献48
-
1毛青,江基尧.颅脑外伤后继发性脑损害发病机制的研究进展[J].中华神经医学杂志,2005,4(2):200-202. 被引量:25
-
2毛青,江基尧.抑制Na^+内流与神经保护作用[J].国外医学(神经病学.神经外科学分册),2005,32(1):15-18. 被引量:5
-
3Bullock R, Zauner A, Woodward JJ, et al. Factors affecting excitatory amino acid release following severe human head injury. J Neurosurg, 1998, 89: 507-518.
-
4Leker RR, Shohami E. Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Rev, 2002, 39: 55-73.
-
5Taylor CP, Meldrum BS. Sodium channels as targets for neuroprotective drugs. Trends in Pharmacological Sciences, 1995,16: 309-316.
-
6Bonoczk P, Gulyas B, Adam-Vizi V, et al. Role of sodium channel inhibition in neuroprotection: effect of vinpocetine.Brain Res Bull, 2000, 53: 245-254.
-
7Hemmings HC. Neuroprotection by Na^+ channel blockade. J Neurosurg Anesthesiol, 2004, 16: 100-101.
-
8Schmued LC, Albertson C, Slikker W Jr. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res, 1997, 751:37-46.
-
9Schmued LC, Hopkins K. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration.Brain Res, 2000, 874: 123-130.
-
10Kahraman S, Ozgurtas T, Kayali H, et al. Monitoring of serum ionized magnesium in neurosurgical intensive care unit:preliminary results. Clin Chim Acta, 2003, 334: 211-215.
共引文献28
-
1余国峰,黄强,戴伟民.镁离子制剂对重型颅脑损伤患者的治疗作用[J].浙江创伤外科,2007,12(4):328-329.
-
2王毅,杨芳,翟宝进,焦德让.症状性脑动脉狭窄支架置入前预应用兴奋性氨基酸的作用[J].中国组织工程研究与临床康复,2008,12(9):1625-1628. 被引量:2
-
3孟祥云.脑外伤术后脑梗死的临床分析[J].中国实用神经疾病杂志,2008,11(5):75-76. 被引量:1
-
4李冰,闫华,只达石,刘暌.颅脑创伤研究的回顾(2006~2007年)[J].医学综述,2008,14(22):3441-3444. 被引量:2
-
5严志忠,毛青,钱忠心,赵鸿,龚良,刘卫东.血镁水平对重型颅脑外伤患者预后的影响[J].上海交通大学学报(医学版),2008,28(12):1561-1563. 被引量:1
-
6严志忠,毛青,钱忠心,赵鸿,龚良,刘卫东.血清镁水平与颅脑损伤严重程度的关系及其对预后的影响[J].中国临床神经外科杂志,2009,14(1):30-32. 被引量:7
-
7毛青,贾锋,张晓华,邱永明,葛建伟,吴日乐,张兴福,罗其中,江基尧.大鼠颅脑创伤后Na_V1.6在海马的表达[J].上海交通大学学报(医学版),2009,29(4):399-403. 被引量:1
-
8于挺敏,姚刚.镁对缺血性脑损害的保护作用[J].中国老年学杂志,2009,29(10):1310-1312. 被引量:4
-
9吴杰,陶进.硫酸镁对急性重型颅脑损伤患者血清S100B浓度和预后的影响[J].国际神经病学神经外科学杂志,2009,36(3):197-200. 被引量:2
-
10只达石,张国斌,闫华.颅脑创伤基础与临床研究十年回顾[J].中国现代神经疾病杂志,2010,10(1):83-91. 被引量:13
-
1谭晓冬,许尚臣,孙若鹏.AMPA受体与缺血性脑损伤[J].国外医学(脑血管疾病分册),2002,10(2):137-139. 被引量:1
-
2李忠玉,刘庆莹,朱长庚,王伟.马桑内酯激活的星形胶质细胞条件培养液及CNQX对正常大鼠脑内及培养的神经元内NSF的影响[J].解剖学报,2007,38(6):636-641.
-
3何小明,梅元武.兴奋性氨基酸受体对大鼠坐骨神经切断后脊髓神经细胞的影响[J].中国临床康复,2003,7(16):2306-2307. 被引量:7
-
4魏辉明,李治贵,普俊杰.α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体拮抗剂对神经病理性痛大鼠海马长时程增强的影响[J].中华临床医师杂志(电子版),2017,11(5):770-773.
-
5何小明,梅元武.AMPA受体对大鼠坐骨神经损伤后神经再生的影响[J].中国临床康复,2004,8(25):5278-5279.
-
6易春霞,雷君,茹立强,孟宪芳.兴奋性氨基酸受体与内脏伤害性信息传入的实验研究[J].华中科技大学学报(医学版),2004,33(6):663-668. 被引量:3
-
7刘慧,问黎敏,乔卉,安书成.高半胱氨酸对慢性应激性抑郁大鼠海马谷氨酸及其受体的调节[J].生理学报,2013,65(1):61-71. 被引量:7
-
8潘卫东,方正龙,刘云,郭伸.肌萎缩性侧索硬化症和兴奋性氨基酸[J].中国临床神经科学,2009,17(1):100-105. 被引量:7