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颅脑外伤后的靶向神经保护

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摘要 颅脑外伤是当今威胁人类生命的主要疾患之一。在颅脑外伤后的神经保护方面,缺乏有效的药物治疗是目前一个备受关注的问题。近年来研究证实:AMPA受体拮抗剂、多种酶抑制剂、米诺环素和雌激素等具有神经保护作用。
出处 《国际神经病学神经外科学杂志》 2008年第3期221-224,共4页 Journal of International Neurology and Neurosurgery
基金 国家自然科学基金资助项目(30371454) 联合基金(GM)资助项目(30422201)
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参考文献25

  • 1Thurman DJ, Alverson C, Dunn KA, et al. Traumatic brain injury in the United States: A public health perspective. J Head Trauma Rehabil, 1999, 14 (6) : 602-615.
  • 2Marklund N, Bakshi A, Castelbuono DJ, et al. Evaluation of pharmacological treatment strategies in traumatic brain injury. Curr Pharm Des, 2006, 12(13) :1645-1680.
  • 3Matucz E, Moricz K, Giqhr G, et al. Reduction of cerebral infarct size by non-competitive AMPA antagonists in rats subjected to permanent and transient focal ischemia. Brain Res, 2004, 1019(1-2) :210-216.
  • 4Belayer L, Alonso OF, Liu Y, et al. Talampanel, a novel noncompetitive AMPA antagonist, is neuroprotective after traumarie brain injury in rats. J Neurotrauma, 2001, 18 (10).1031-1038.
  • 5Furukawa T, Hoshino S, Kobayashi S, et al. The glutamate AMPA receptor antagonist, YM872, attenuates cortical tissue loss, regional cerebral edema, and neurological motor deficits after experimental brain injury in rats. J Neurotrauma, 2003, 20(3) :269-278.
  • 6Weiser T. AMPA receptor antagonists with additional mechanisms of action: new opportunities for neuroproteetive drugs ? Curr Pharm Des, 2002, 8(10) :941-951.
  • 7Wang KK. Calpain and easpase : can you tell the difference ? Trends Neurosci, 2000, 23 ( 1 ) : 20-26.
  • 8Kupina NC, Nath R, Bemath EE, et al. The novel ealpain inhibitor SJA6017 improves functional recovery after delayed administration in a mouse model of diffuse head injury. J Neuotrauma, 2001, 18(11) :1229-1240.
  • 9Shirasaki Y, Miyashita H, Yamaquchi M, et al. Exploration of orally available calpain inhibitors: peptidyl alpha-ketoamides containing an amphiphile at P3 site. Bioorg Med Chem, 2005, 13(14) :4473-4484.
  • 10Han BH, Xu D, Choi J, et al. Selective, reversible caspase-3 inhibitor is neuroprotective and reveals distinct pathways of call death after neonatal hypoxic-ischemic brain injury. J Biol Chem, 2002, 277(33) : 30128 -30136.

二级参考文献48

  • 1毛青,江基尧.颅脑外伤后继发性脑损害发病机制的研究进展[J].中华神经医学杂志,2005,4(2):200-202. 被引量:25
  • 2毛青,江基尧.抑制Na^+内流与神经保护作用[J].国外医学(神经病学.神经外科学分册),2005,32(1):15-18. 被引量:5
  • 3Bullock R, Zauner A, Woodward JJ, et al. Factors affecting excitatory amino acid release following severe human head injury. J Neurosurg, 1998, 89: 507-518.
  • 4Leker RR, Shohami E. Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Rev, 2002, 39: 55-73.
  • 5Taylor CP, Meldrum BS. Sodium channels as targets for neuroprotective drugs. Trends in Pharmacological Sciences, 1995,16: 309-316.
  • 6Bonoczk P, Gulyas B, Adam-Vizi V, et al. Role of sodium channel inhibition in neuroprotection: effect of vinpocetine.Brain Res Bull, 2000, 53: 245-254.
  • 7Hemmings HC. Neuroprotection by Na^+ channel blockade. J Neurosurg Anesthesiol, 2004, 16: 100-101.
  • 8Schmued LC, Albertson C, Slikker W Jr. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res, 1997, 751:37-46.
  • 9Schmued LC, Hopkins K. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration.Brain Res, 2000, 874: 123-130.
  • 10Kahraman S, Ozgurtas T, Kayali H, et al. Monitoring of serum ionized magnesium in neurosurgical intensive care unit:preliminary results. Clin Chim Acta, 2003, 334: 211-215.

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