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空肠弯曲杆菌感染与吉兰-巴雷综合征及Fisher综合征 被引量:2

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摘要 吉兰-巴雷综合征(GBS)是一种危害严重的急性周围神经病,目前认为与空肠弯曲杆菌(Cj)的前驱感染有关。Cj脂低聚糖(LOS)与神经节苷脂的化学结构存在相同的部分。唾液酸转移酶基因(Cst-II)是Cj合成神经节苷酯样的LOS必需的基因,其第51个氨基酸(Thr/Asn即苏氨酸/天门冬酰胺)决定了其酶活性。宿主感染带有Cst-II的Cj后,Cj可以合成神经节苷酯样的LOS,使机体免疫系统发生错误的识别,引起GBS及Fisher综合征。
作者 于欣欣 任惠
出处 《国际神经病学神经外科学杂志》 2008年第3期271-274,共4页 Journal of International Neurology and Neurosurgery
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