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CXC趋化因子受体3及其配体与实验性自身免疫性脑脊髓炎

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摘要 实验性自身免疫性脑脊髓炎(EAE)是由CD4+T细胞介导的自身免疫性中枢神经系统脱髓鞘炎症。以往认为,中和CXC趋化因子受体3(CXCR3)或其配体(CXCL10)可以缓解EAE的病情,减少复发。但近年来研究发现CXCR3或CX-CL10基因敲除能够加重EAE病情,提示它们可能对EAE起保护性作用。本文就CXCR3及其配体CXCL10与EAE的发生发展之间的联系以及相关的调节机制进行综述,为CXCR3受体拮抗剂或CXCL10中和剂在临床上的应用提供理论参考。
作者 夏念格 郑荣远
机构地区 温州医学院附属第一医院神经内科
出处 《国际神经病学神经外科学杂志》 2008年第3期281-285,共5页 Journal of International Neurology and Neurosurgery
关键词 实验性自身免疫性脑脊髓炎 CXC趋化因子受体3 CXCL10
分类号 R744 [医药卫生—神经病学与精神病学]
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国际神经病学神经外科学杂志
2008年 第3期

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