摘要
目的探讨原发性胃淋巴瘤（PGL）的临床特点及诊治方法。方法回顾性分析中国医学科学院肿瘤医院1994年1月至2006年12月所收治的98例PGL患者的临床资料，总结其临床特点和治疗方式对患者生存期的影响。结果腹痛为本组病例最常见的临床症状，占51．0％。患者全部为Ⅰ、Ⅱ期肿瘤；PGL术前的确诊率为56．5％，1、3、5年总生存率分别为95．1％、86．0％和73．0％；Ⅰ期患者的5年生存率为89．5％，Ⅱ期患者为66．7％，两者差异有统计学意义（P=0．029）。手术治疗组患者5年生存率77．2％，非手术治疗组患者为75．0％，两者差异无统计学意义（P=0．794）。结论对于PGL，可首选全身化疗为主的治疗模式；在出现严重的消化道并发症、无明确活检病理诊断或化疗无效时可考虑手术治疗。
Objective To explore the clinical characteristics, diagnosis and treatment regimens for the primary gastric lymphoma（PGL）. Methods The data of 98 PGL patients treated from January 1994 to December 2006 were collected and analyzed retrospectively. Results Abdominal pain was the common symptom of PGL. All the patients were at stage Ⅰ or stage Ⅱ, and the preoperative diagnosis rate was 56.5%. The overall 1-, 3- and 5-year survival rates were 95.1%, 86.0% and 73.0% respectively. The 5-year survival rates of stage Ⅰ and stage Ⅱ patients were 89.5% and 66.7% respectively, and the difference was significant. The 5-year survival rate of patients received operations was 77.2% and that without operation was 75.0%, the difference was not significant. Conclusions The therapy based on chemotherapy is preferred for the treatment of PGL. In the cases of serious gastrointestinal complications, indefinite pathological diagnosis or non-effective chemotherapy, operations should be considered.
出处
《中华胃肠外科杂志》
CAS
2008年第4期326-330,共5页
Chinese Journal of Gastrointestinal Surgery
关键词
胃肿瘤
淋巴瘤
预后
诊断
治疗
Stomach neoplasms
Lymphoma
Prognosis
Diagnosis
Treatment
