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2型糖尿病血管并发症患者细胞间黏附分子-1基因多态性研究 被引量：2

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摘要 目的研究细胞间黏附分子-1(ICAM-1)469K>E基因多态性位点等位基因分布频率及其与2型糖尿病(T2DM)血管病变的关系。方法采用聚合酶链式反应(PCR)方法检测62例T2DM血管并发症患者ICAM-1469KK、KE及EE基因型出现的频率。并检测其空腹血糖(BS)、甘油三酯(TG)、糖化血红蛋白(HbA1c)、血浆游离ICAM-1(sICAM-1)和总胆固醇(TC)水平,并与70例无血管并发症的T2DM患者及121例正常对照组比较。结果KK、KE、EE3种基因型在3组中的分布频率有明显差异(χ2=6·313,P=0·043),DM血管病变组等位基因E的频率明显高于对照组和无血管病变组(P<0·01),T2DM血管病变组ICAM-1469E等位基因携带者sICAM-1水平明显高于K等位基因携带者(P<0·01)。结论ICAM-1469E等位基因与DM血管病变及ICAM-1水平升高有关。
作者 毛达勇 周有利 丁嫣
机构地区 湖北省郧阳医学院附属太和医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2008年第13期1288-1290,共3页 Chinese Journal of Gerontology
关键词 2型糖尿病 血管并发症 细胞黏附分子-1 基因多态性
分类号 R446.1 [医药卫生—诊断学]
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中国老年学杂志
2008年 第13期

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