精神分裂症与5HT2a受体基因T102C多态性的关联研究

A study on the association of 5HT2a receptor gene T102C polymorphism and schizophrenia

目的 探讨汉族人5-HT2a受体基因T102C多态性与精神分裂症病因之间的关系。方法 取223例精神分裂症病人作研究,以162例正常人作对照。用聚合酶链式反应(PCR)扩增及内切酶酶切技术测定所研究对象的基因型和等位基因。结果 发现精神分裂症与5-HT2a受体基因的基因型A1/A1关联。结论 5-HT2a受体基因T102C多态性与精神分裂症的易感性有关,基因型A1/A1是精神分裂症的风险因子。

Objective : To investigate the relationship between schizophrenia and T102C polymorphism of 5HT2a receptor gene. Methods: The genotypes and alleles of 233 schizophrenic patients and 162 healthy controls were examined with the PCR amplification and the restrict enzyme digestion methods. The genetic association was estimated. Results: A significant association between schizophrenia and the genotype A1/A1 of 5HT2a receptor gene was revealed. Conclusion: It is suggestd that the T102C polymorphism of 5HT2a receptor gene might contribute to the susceptibility of schizophrenia, and the genotype Al/Al might be the risk factor.