自适应光学系统在青光眼视网膜毛细血管中的观察

Preliminary observation of the glaucomatic retinal capillaries by adaptive optics

目的以自适应光学系统观测青光眼患者的视网膜毛细血管特征。方法用37单元活体人眼视网膜高分辨率成像系统,对18岁以上原发性开角型青光眼患者和健康对照者的视网膜毛细血管,以中心小凹向下旁开1°的位置进行成像,比较其成像结果和数据,并进行统计学检验。结果健康对照组清晰成像者5例,原发性开角型青光眼组4例。健康对照组的平均毛细血管直径(5.39μm)大于原发性开角型青光眼组(3.91μm),差异有统计学意义(P=0.047)。两组的血管总长度及血管条数未见明显差别。结论黄斑区视网膜毛细血管在原发性开角型青光眼患者中变细,这可能是血管自我调节异常的一种表现。

Objective To detect the characteristics of retinal capillaries of glaucomatic patients by using adaptive optics system. Methods Retinal capillaries of normal people and primary open-angle glaucomatic patients over 18 years old were detected by using 37 unit high resolution retinal imaging system. The images were taken 1 degree below the foveola. The data were statistically tested. Results Five clear images in normal group and 4 clear images in primary open-angle glaucomatic group were evaluated. The mean diameter of the capillaries in the normal group（5.39μm） was significantly larger than that in the glaucomatic group（3.91μm） （P =0.047）. No obvious differences in the total length and the number of the vessels were found between the two groups. Conclusions The macular retinal capillaries in the primary open-angle glaucomatic patients became thinner,which might be an appearance of the vascular automatic dysregu-lation.