丹参对急性肝损害大鼠体内血栓素、前列环素的作用

Effect of Salvia Miltiorrhiza Bunge on the Levels of TXA_2 and PGI_2 in Rats with Acute Liver Injury

通过动物实验观察丹参对急性肝损害的保护作用及丹参对炎性介质血栓素（TXA2）、前列环素（PGI2）的影响。结果显示：损伤组大鼠血浆血栓素B2（TXB2）为（782．73±577．16）ng／L，而实验组为（34．93±272．49）ng／L，显著低于损伤组（P＜0．05）。两组血浆6－酮－前列腺素F1a分别为（23．27±13.45）和（26.67±12.52）ng／L，差异不显著。血浆TXB2与脂质过氧化物水平呈正相关（r=0.668，P＜0．01）。实验组血谷丙转氨酶、谷草转氨酶活性低于损伤组，肝脏病理损害减轻。结果提示：丹参可抑制缩血管介质TXA2的增高，对急性肝损害有保护作用。

The purpose of this study was to observe the effect of salvia miltiorrhiza bunge (SMB) onacute liver injury and on the plasma levels of TXA2 and PGI2 of rats. The results showed that the plasma levelsof TXB2 in the experimental group were obviously lower than those in the damage group (340. 93±272. 49ng/L vs 782. 73±577. 16ng/L, P <0. 05). But there was no difference in plasma levels of 6-keto-PGF. intwo groups (23. 27±13. 45 vs 26. 67±12. 52 ng/L). Plasma levels of TXB2 showed positive correlation withplasma levels of lipid peroxide. In the experimental group,the ALT and AST were markedly decreased,andhepatic histoeathology attenuated. The results suggest that SMB can limit the increase of TXA2 and showprotective effects on acute liver injury.