摘要
选择30例胆囊结石并慢性胆囊炎患者，分别行腹腔镜和剖腹胆囊切除术各15例。于术前、术后第1、3、7d采血分别测定血中免疫球蛋白及补体含量，T淋巴细胞亚群和白介素-2（IL-2）及白介素-6（IL－6）的水平。结果发现：①腹腔镜组免疫球蛋白及补体水平手术前后无变化，而剖腹组IgG和C3术后均低于术前水平，两组间差异无显著性（P＞0．05）；②开腹组CD3、CD4细胞百分比及IL－2水平术后均低于腹腔镜组，两组间有显著性差异（P＜0．01，＜0．05，＜0．01）；IL－6的水平术后剖腹组明显高于腹腔镜组（P＜0．01）。研究表明，腹腔镜手术对免疫功能的抑制程度较轻，似可说明，腹腔镜手术对机体的创伤较剖腹手术小。
Immune function was examined in patients undergoing laparoscopic (n=15) and open(n=15) cholecystectomy for chronic cholecystitis and gallstones. Patients were matched for age, sex, height,weight and operation time. Immune parameters including serum immuoglobulins (IgG,IgA,IgM) andcomplements (C3, C4). T Cell subsets,and interleukin-2 and interleukin-6 levels were assessed preoperativelyand on postoperative days 1, 3 and 7. The results showed that ① The levels of serum immuoglobulins andcomplements didn't change after laparoscopic cholecystectomy (LC),but the levels of serum IgG and C3 weresignificantly decreased after open cholecystectomy (OC) (P<0. 05). There was no significant differencebetween two groups. ② OC patients showed a significantly greater postoperative decrease of blood CD3 count (P<0. 01),of blood CD. count (P<0. 05) and of IL-2 level (P<0. 01). Moreover, after OC a significantlygreater increase of IL-6 level was found, as compared to LC. These findings suggest that LC causes lessdepression of immune function than OC. It appears that laparoscopic procedure is less traumatic.
出处
《同济医科大学学报》
CSCD
1997年第6期457-460,共4页
Acta Universitatis Medicinae Tongji
基金
国家教委资助
