妊娠肝内胆汁淤积症对围生儿预后影响因素的探讨

Discuss on influence factor of intrahepatic cholestasis of pregnancy on perineonate prognosis

目的探讨妊娠肝内胆汁淤积症(ICP)对围生儿预后的影响因素。方法对357例ICP孕妇的各项化验指标及围生儿预后进行回顾性分析。结果在非胎儿窘迫与胎儿宫内窘迫组间,只有总胆汁酸(TBA)有显著性差异(P<0.05)。随着TBA水平增高,胎儿宫内窘迫发生率、早产儿发生率渐增高,胎窘组与非胎窘组、早产组与非早产组、巨大儿组与非巨大儿组TBA值比较均有显著性差异(P均<0.05)。结论ICP孕妇TBA增高与围生儿预后有关,必须高度重视。

Objective It is to discuss the influence factor of intrahepatic cholestasis of pregnancy （ICP） on perineonate prognosis. Methods All chemical examination index of 357 ICP gravida and perineonate prognosis were retrospectively analyzed, Results There was significant difference on total bile acid （TBA） only between non-intra-uterine asphyxia group and intra-uterine asphyxia group （P 〈 0.05）. Along with TBA level heightening, the incidence rates of intra-uterine asphyxia and premature infant were gradually heightened. There were significant differences on TBA level between non-intra-uterine asphyxia group and intra-uterine asphyxia group, between preterrn labor group and non-preterrn labor group and between macrosomia group and non-macrosomia group （ P 〈 0.05 ）. Conclusion TBA level of ICP gravida heightening has relation with perineonate prognosis, which must be caused high attention.