L-精氨酸治疗胎儿生长受限胎儿发育的临床观察

Clinical study on treatment of L-arginine to fetal growth restriction.

目的通过L-精氨酸治疗对胎儿生长受限的临床观察,探讨L-精氨酸对胎儿生长受限的治疗效果。方法将胎儿生长受限患者60例,随机分为常规治疗组(A组)30例,L-精氨酸治疗组(B组)30例,孕期定期用B型超声监测两组胎儿生长发育参数,产后比较新生儿出生体重和围产儿结局。结果生长参数:治疗后A组与B组比较,B组双顶径(BPD)、股骨长(FL)及腹围(AC)的增长幅度较高(P均<0.05)。新生儿出生体重和围产儿结局:B组的治愈率显著高于A组(P<0.05),新生儿平均出生体重高于A组,小于胎龄儿(SGA)的发生率低于A组。结论L-精氨酸治疗较常规治疗疗效更显著,能更好地增加胎儿体重促进胎儿发育。

Objectives ： To study the effect of L - arginine to fetal growth restriction （FGR） by observing development and growth and other index of fetal . Methods ： Chose 60 cases confirmed FGR patients, among which 30 cases were treated with conventional ways was named group A, the other 30 cases were treated with L - arginine was named group B. We monitored the parameters in development and growth of fetal, and compared the birth weight and perinatal fetus outcome. At last the data were analyzed by SPSS11.5 software. Results： The parameters in development and growth of fetal： Compared with group A , the BPD, FL and AC of groupB increased significantly （ P 〈 0. 05 ）. The birth weight and perinatal fetus outcome ： Compared with group A the healing rate of group B is higher and the birth weight of group B is higher too, at the same time the incidence of newborns with SGA was significantly lower than that of group A. Conclusion ： The curative effect of L - arginine combined with convention therapy is higher than that of rou- tine therapy only. L - arginine could improve the weight and increase the development of fetal.