6-溴-4-烃硫基喹唑啉类化合物的合成及抑菌活性研究

Synthesis and Antifungal Bioactivity of 6-Bromo-4-alkylthioquinazoline Derivatives

以6-溴-4-巯基喹唑啉和卤代烃为原料,用相转移催化法合成了10个新的6-溴-4-烃硫基取代喹唑啉类化合物.化合物经1HNMR,13CNMR,IR及元素分析证明其结构.初步生物活性试验结果表明,在50mg?L-1浓度下,化合物6g对小麦赤霉病菌、辣椒枯萎菌、苹果腐烂菌抑制率分别为63.8%,51.9%,55.1%,与对照药剂恶霉灵抑制活性相当.

Ten new 6-bromo-4-alkylthioquinazoline compounds were synthesized by the reaction of 6-bromo-4-thiolquinazoline with alkylhalide under the conditions of phase-transfer catalysis. The structures of the new compounds were characterized by ^1H NMR, ^13C NMR, IR spectra and elemental analyses. Bioactivity of the new compounds was tested. The preliminary bioassay showed that compound 6g had certain antifungal activities against Fusarium graminearum, Cytospora mandshurica and Fusarium oxysporum with rate of 63.8%, 51.9% and 55.1% at the concentration of 50 mg·L^-1, respectively, similarly to that of control （hymexozole）.