Toll样受体与侵袭性肺曲霉病研究进展

Recent advances in relationship between Toll-like receptor and invasive pulmonary aspergillosis

近年来，侵袭性肺曲霉病（invasive pulmonary aspergillosis，IPA）的发病率呈上升趋势，严重威胁着免疫缺陷患者的生命。Toll样受体（Toll—like receptor，TLR）是一种病原体相关的分子模式识别受体。体内、体外实验均表明，TLR在IPA发病过程中发挥着重要作用，其中最为重要的是TLR2和TLR4。

The morbility of invasive pulmonary aspergillosis（IPA） has represented a raising trend in recent years. IPA seriously threatens the immunocompromised patients＇ lives. Toll like receptor（TLR） can recognize the pathogen-associated molecular patterns. In vivo and in vitro experiments have indicated that TLR plays a vital role in the pathogenesis of IPA,in which TLR2 and TLR4 are the most important.