128例乳头溢血的临床病理分析

Clinical and pathological analysis of 128 cases bloody nipple discharge

目的寻找乳头溢血的常见病因以及恶性溢血的临床病理特征。方法回顾性分析128例乳头溢血的临床病理特点，探讨乳腺导管癌与某些临床病理特征（年龄、病变部位、有无钙化、导管瘤病史）的相关性。结果128例乳头溢血中，乳腺导管肿瘤性病变105例（82．03％），非肿瘤性病变23例（17．97％）。肿瘤性病变中导管癌26例，年龄〉150岁、病变位置在Ⅲ级及以下导管、钼靶片示钙化灶，有导管瘤病史者患导管癌的可能性较大，其差异均有显著性（P〈0．05）。结论乳头溢血多见于乳腺导管肿瘤性病变；年龄≥50岁、有导管瘤病史、病变位于Ⅲ级及以下导管、伴有微钙化是患乳腺导管癌的高危因素，临床需高度重视。

Objective To investigate the pathogenesis of bloody nipple discharge and the clinical and pathological characteristics of malignant nipple discharge. Methods 128 cases bloody nipple discharge and the correlation between breast cancer and some clinical - pathological characteristics such as age, location of lesion, calcification and previous ductal tumor history were retrospectively reviewed. Results There were 105 patients with breast ductal tumor and 23 with non - tumor lesion in all these patients. Of all the breast ductal tumor, 26 were breast ductal carcinoma featured by aged over 50 years old, location of lesion at the third grade or lower duct, mammographic microcalcification and previous ductal tumor history（p 〈 0. 05 ）. Conclusion The majority of nipple bloody discharge are breast ductal tumors. Aged over 50 years old, location of lesion at the third grade or lower duct, mammographic microcalcification and previous ductal tumor history are risk factors for breast ductal carcinoma.