红霉素治疗重度反流性食管炎的疗效观察

Curative of Erythromycin for Serious Reflux Esophagitis

目的研究红霉素对重度反流性食管炎的疗效。方法将67例重度反流性食管炎患者随机分为治疗组(34例)和对照组(33例),对照组予口服奥美拉唑、莫沙必利及改变生活方式与饮食习惯等综合治疗,治疗组在综合治疗的基础上加服红霉素0.125g,3次/d。于治疗8周后复查胃镜,观察镜下愈合率。结果治疗组内镜下有效率91.2%;对照组内镜下有效率69.7%,2组比较差异有统计学意义。结论在口服奥美拉唑、莫沙必利等综合治疗的基础上加服红霉素明显提高重度反流性食管炎的疗效。

Objective To study the efficacy of Erythromycin in treating serious reflux esophagitis. Methods 67 cases with serious reflux esophagitis were divided into two groups randomly. Group A（ control group, n = 34） were given omeprazole and mosapride based on improving patient＇ s life style and food habit, etc. ; and group B （ control group, n = 33 ） were given additional Erythromycin, At the end of 8th weeks,the healing rate was rechecked by endoscope, Results The efficient rates evaluation under endoscope was 91.2% in group A and 69.7% in group B respectively, and there was statistic difference. Conclusions Additional Erythromycin based on administering of omeprazole and mosapride can effectively improve the curative effect in the treatment of serious reflux esophagitis.