浅表性膀胱癌术后不同剂量卡介苗膀胱灌注的疗效比较

Comparison of the effect of BCG intro vesical instillation of different dose for superficial TCC

目的比较浅表性膀胱癌术后不同剂量卡介苗(BCG)膀胱灌注的疗效。方法浅表性膀胱癌患者术后随机接受120mg、60mg和30mg三种不同剂量的BCG膀胱灌注,随访6-24个月,选取临床和随访资料完整病例241例,评判灌注后不良反应发生和肿瘤复发的情况。结果60mg剂量组膀胱灌注毒副反应较120mg剂量组轻(P<0.05),较30mg剂量组肿瘤复发率低(P<0.05)。结论与120mg和30mg相比,BCG灌注剂量为60mg时副反应更轻,肿瘤复发率更低。

Objective To evaluate the effect of intro vesical instillation of BCG of different doses for superficial transitional cell carcinoma （TCC）. Methods 241 patients of superficial TCC were divided into 3 groups randomly. The dose of BCG for each group was 120 mg, 60 mg and 30 mg. All patients were followed up for 6--24 months. The recurrence rate and toxic side effects of BCG were observed. Results The toxic side effects of 60 mg was lower than 120 mg （P〈0.05）, and the recurrence rate of bladder cancer in the 60 mg group was lower than that in the 30 mg group （P〈0.05）. Oonclusion Compared with other 2 groups, 60 mg BCG used for intro vesical instillation has fewer side effect and better effect to prevent local recurrence.