盐酸多奈哌齐对轻、中型脑外伤患者认知障碍的治疗作用

Therapeutic Effects of Donepezil on the Cognitive Impairment Following Light and Moderate Traumatic Brain Injury

目的探讨盐酸多奈哌齐对轻、中型脑外伤患者认知障碍及临床预后的影响。方法78例轻、中型脑外伤并认知障碍患者被随机分成治疗组和对照组,治疗组应用盐酸多奈哌齐10mg/d,对照组应用吡拉西坦8mg,一日3次服用,两组的治疗周期为12周。治疗前及治疗后12周,分别应用简明精神状态检测量表(MMSE)、国人修订成人韦氏智利量表(WAIS-RC)和格拉斯哥预后评分(GOS)评价疗效。结果两组在治疗后12周,MMSE和WAIS-RC评分均较治疗前提高(P<0.05)。治疗后12周,治疗组MMSE和WAIS-RC评分较对照组高(P<0.05),治疗组GOS预后优良率明显优于对照组(P<0.05)。结论盐酸多奈哌齐对轻、中型脑外伤后认知障碍有积极治疗作用,并能改善临床预后。

Objective To investigate the therapeutic effects of donepezil on the cognitive impairment and clinical prognosis after light and moderate traumatic brain injury（TBI）. Methods 78 patients with cognitve impairment following light and moderate TBI were randomly divided into therapy group and control group. The therapy group was administrated with donepezil 10 mg./d for 12 weeks and the control group with piracetan 800 mg/d for 12 weeks. All patients were assessed with Mini Mental State Examination（MMSE）, Wechsler Adult Intelligence Tevised in China （WAIS-RC）, and Glasgow Prognosis Score before and 12 weeks after treatment. Results Both MMSE and WAIS-RC scores are improved in the two groups at 12 weeks after the treatment. The therapy group produced significantly better scores on MMSE and WAIS-RC then the control group at 12 weeks after the treatment （P〈0.05）, and the clinical prognosis also significantly improved after the treatment （P〈0.05）. Conclusion The donepezil can significantly improve the cognitive impairment and clinical prognosis following light and moderate TBI.