摘要
目的观察分析2型糖尿病患者载脂蛋白A(apoA)水平变化与血糖控制状态关系及其可能的影响机制。方法采用自动生化仪检测213名2型糖尿病患者血浆总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、极低密度脂蛋白(VLDL)、低密度脂蛋白(LDL)、载脂蛋白A(apoA)、载脂蛋白B(apoB),用离子交换高效液相色谱分析法测定糖化血红蛋白(HbA1c),比较其与血脂指标的相关性。结果两组HDL-C水平差异无统计学意义[(1.26±0.45)mmol/L vs(1.13±0.35)mmol/L,P>0.05];控制满意组apoA水平显著高于非满意组[(1.16±0.31)g/L vs(0.98±0.32)g/L,P<0.01],apoB/apoA显著低于非满意组(P<0.05)。TC、TG、LDL、VLDL水平两组差异无统计学意义(P>0.05)。直线相关分析显示apoA与HbA1c、FBG呈显著负相关(r=-0.30,P<0.01;r=-0.24,P<0.01);apoA与HDL、TC呈显著正相关(r=0.74,P<0.01;r=0.39,P<0.01)。结论2型糖尿病患者血糖控制状态显著影响apoA水平,这可能是HDL功能紊乱的重要原因。
Objective To investigate the effect of glycaemic control on serum apoA levels in patients with type 2 diabetes. Methods 213 type 2 diabetic patients were fasting sampled, and serum concentrations of triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A(apo A) and B(apo B) were measured by biochemical assays, while plasma HbAlc was determined by HPLC. Correlations between apoA and other lipid-related parameters were statistically analyzed by Pearson's correlation. Results Patients were divided to good-control group (HbAlc≤7.0%, n=68) and poor-control group (HbAlc〉7.0%, n=i35)according to the guideline of ADA 2007. Serum levels of TG, TC, LDL-C, HDL-C and apoB were comparable between 2 groups. Serum apoA was significantly higher in good-control patients than in poor-control individuals [ (1.16±0.31) g/L vs (0.98±0.32) g/L, P〈0.01 ], hence apoB/apoA ratio decreased in the former group. In all patients, apoA was negatively correlated with HbAlc (r=-0.30, P〈0.01 ), and positively correlated with HDL (r=0.74, P〈0.01). Conclusion State of glycaemic control exerts powerful effects on serum apoA in type 2 diabetic patients, which may play important roles in dysfunction of HDL molecules.
出处
《热带医学杂志》
CAS
2008年第7期694-696,共3页
Journal of Tropical Medicine
关键词
2型糖尿病
糖化血红蛋白
载脂蛋A
type 2 diabetes
glycosylated hemoglobin
apolipoprotein A