子宫性索样肿瘤2例及文献分析

Two cases report of uterine sex cord-like tumor and literature review

目的报告2例子宫性索样肿瘤(USCT),探讨其临床病理特征与生物学行为。方法观察2例USCT的临床表现、发生部位、光镜形态与免疫表型。结果2例肿瘤分别发生于宫体与宫颈。肿瘤上皮样细胞呈巢状、索状、梁状等性索状排列,部分细胞胞质泡沫状。免疫组化2例均表达CK(广谱)、CD99、SMA、Vimentin、CD10,1例表达CD117。结论USCT可发生于宫体与宫颈,光镜与免疫表型兼具上皮、性索、平滑肌与子宫内膜间质的部分特征,生物学行为有待更多病例的积累。

Objective To report two cases of the uterine sex cord - like tumor （USCT）, and analyze the clinicopathological features and its biology behavior. Methods The clinicopathological features include the tumors＇ location, the microscopic findings and immunophenotype were observed. Results The USCTs were found in the uterine corpus and the cervix respectively. The epithelial - like cells were aligned in cords, nests and trabecular rib- bons. Some of the cells had foamy cytoplasm. In both cases, the tumor cells presented positive signal of CK, CD99, SMA, Vimentin and CD10, and one was positive for CDllT. Conclusions USCT may occur in uterine corpus or cervix, and may show the some of the features of epithelial, sex-cord, smooth muscles and endometrial stromal cells. The reports of USCT were limited and its behavior and prognosis remains more data and long-term follow-up.