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不同负荷剂量替罗非班对急性心肌梗死介入治疗疗效和安全性评价

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摘要 替罗非班是一种高选择性、高特异性的非肽类小分子血小板膜糖蛋白Ⅱb／Ⅲa受体拮抗剂，通过抑制纤维蛋白原与血小板表面Ⅱb／Ⅲa受体结合，具有抗血小板、抗栓作用^[1]。由于常规剂量替罗非班起效较慢，有研究表明，应用加倍负荷剂量替罗非班（20 μg／kg，继以0．15 μg·kg^-1·min^-1静脉滴注持续24h）较常规剂量（10 μg／kg，继以0．15 μg·kg^-1·min^-1静脉滴注持续24h）起效更快，
作者 黄伟剑 周浩 吴钟伟 计光 李晟 吴高俊 张怀勤
机构地区 温州医学院附属第一医院心血管内科、温州市心脏介入治疗中心
出处 《中华急诊医学杂志》 CAS CSCD 2008年第7期749-751,共3页 Chinese Journal of Emergency Medicine
关键词 替罗非班 负荷剂量 介入治疗疗效 急性心肌梗死 安全性评价 血小板膜糖蛋白Ⅱb Ⅲa受体拮抗剂 非肽类小分子
分类号 R542.22 [医药卫生—心血管疾病]
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参考文献10

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中华急诊医学杂志
2008年 第7期

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